Rchr
J-GLOBAL ID:201601013970746240
Update date: Jan. 30, 2024
Tomohito Higashi
ヒガシ トモヒト | Tomohito Higashi
Affiliation and department:
Research field (2):
Cell biology
, Experimental pathology
Research keywords (13):
クローディン
, プロテアーゼ
, EpCAM
, 動的制御
, TAMP family proteins
, Angulins
, Vinculin
, Formins
, Actin cytoskeleton
, Cytokinesis
, Tricellular junctions
, Cell-cell adhesion
, Tight junctions
Research theme for competitive and other funds (7):
Papers (42):
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Tomohito Higashi, Rachel E Stephenson, Cornelia Schwayer, Karla Huljev, Atsuko Y Higashi, Carl-Philipp Heisenberg, Hideki Chiba, Ann L Miller. ZnUMBA - a live imaging method to detect local barrier breaches. Journal of cell science. 2023. 136. 15
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Akira C Saito, Tomohito Higashi, Hideki Chiba. Tight-junction strand networks and tightness of the epithelial barrier. Microscopy (Oxford, England). 2023. 72. 3. 213-225
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Tomohito Higashi, Akira C Saito, Yugo Fukazawa, Mikio Furuse, Atsuko Y Higashi, Masahiro Ono, Hideki Chiba. EpCAM proteolysis and release of complexed claudin-7 repair and maintain the tight junction barrier. The Journal of cell biology. 2023. 222. 1
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Yuta Endo, Kotaro Sugimoto, Makoto Kobayashi, Yasuyuki Kobayashi, Manabu Kojima, Shigenori Furukawa, Shu Soeda, Takafumi Watanabe, Atsuko Y Higashi, Tomohito Higashi, et al. Claudin-9 is a novel prognostic biomarker for endometrial cancer. International journal of oncology. 2022. 61. 5
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Akira C Saito, Chisato Endo, Yugo Fukazawa, Tomohito Higashi, Hideki Chiba. Effects of TAMP family on the tight junction strand network and barrier function in epithelial cells. Annals of the New York Academy of Sciences. 2022
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MISC (18):
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T. Higashi, S. Tokuda, S-I. Kitajiri, H. Nakamura, Y. Oda, M. Furuse. Analysis of the angulin family consisting of LSR, ILDR1 and ILDR2: tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis. MOLECULAR BIOLOGY OF THE CELL. 2012. 23
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Mikio Furuse, Noriko Iwamoto, Yukako Oda, Tomohito Higashi. The structure of tight junctions in brain endothelial cells. 日本神経科学学会. 2012
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T. Higashi, M. Furuse. ILDR1 and ILDR2 recruit Tricellulin to tricellular tight junctions. MOLECULAR BIOLOGY OF THE CELL. 2011. 22
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Tomohito Higashi, Tomoyuki Ikeda, Takaaki Murakami, Ryutaro Shirakawa, Mitsunori Kawato, Katsuya Okawa, Mikio Furuse, Takeshi Kimura, Toru Kita, Hisanori Horiuchi. Flightless-I (Fli-I) Regulates the Actin Assembly Activity of Diaphanous-related Formins (DRFs) Daam1 and mDia1 in Cooperation with Active Rho GTPase. JOURNAL OF BIOLOGICAL CHEMISTRY. 2010. 285. 21. 16231-16238
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T. Ikeda, H. Horiuchi, T. Higashi, R. Shirakawa, M. Kawato, T. Kita. BIOCHEMICAL CHARACTERIZATION OF THE EFFECTOR MOLECULES OF SMALL GTPASE RHO IN PLATELETS. ATHEROSCLEROSIS SUPPLEMENTS. 2008. 9. 1. 67-67
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Books (1):
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Tight Junctions
2022 ISBN:3030972038
Lectures and oral presentations (11):
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Proteinase-mediated tight junction damage surveillance and repair.
(Shenyang Brain Science and Disease Symposium 2023)
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EpCAMの限定分解による密着結合の修復機構
(生理学研究所上皮研究会 2023)
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Proteinase-mediated tight junction damage surveillance and repair
(Gordon Research Conference (GRC) on Cell Contact and Adhesion 2023)
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Proteinase-mediated tight junction damage surveillance and repair
(2022)
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Occludin and tricellulin regulate the complexity of TJ strand network and epithelial barrier function
(4th International Tight Junction Conference 2021)
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Education (3):
- 2005 - 2008 Kyoto University Graduate School of Medicine Medical Science
- 2003 - 2005 Kyoto University Graduate School of Medicine Medical Science
- 1999 - 2003 Kyoto University Faculty of Science Biology
Professional career (3):
- 博士(医科学) (京都大学)
- 修士(医科学) (京都大学)
- 学士(理学) (京都大学)
Work history (8):
- 2020/03 - 現在 Fukushima Medical University Department of Basic Pathology Associate Professor
- 2018/03 - 2020/02 Fukushima Medical University Department of Basic Pathology Assistant Professor
- 2017/08 - 2018/02 Fukushima Medical University Department of Basic Pathology Assistant Professor
- 2016/04 - 2017/07 University of Michigan Molecular, Cellular, and Developmental Biology Postdoctoral research fellow
- 2014/04 - 2016/03 University of Michigan Molecular, Cellular, and Developmental Biology JSPS Postdoctoral Research Fellow
- 2013/11 - 2014/03 University of Michigan Molecular, Cellular, and Developmental Biology JSPS Postdoctoral Research Fellow
- 2011/04 - 2013/10 Kobe University Graduate School of Medicine JSPS Postdoctoral Research Fellow
- 2008/04 - 2011/03 Kobe University Graduate School of Medicine Postdoctoral fellow (Global-COE)
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Committee career (1):
- 2022/08 - 現在 福島県立医科大学 一般倫理委員会 委員
Association Membership(s) (3):
日本分子生物学会
, 日本細胞生物学会
, American society for cell biology
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