TERUMASA UMEMOTO

Affiliation and department：

Research field (2)： Hematology and oncology , Cell biology

Research theme for competitive and other funds (11)：

2023 - 2026 「硬さ」を計測し操作する造血幹細胞の増殖・分化制御系
2023 - 2026 生体イメージングと網羅的解析によるミトコンドリア面からみた緑内障とその治療法探索
2023 - 2026 クロマチン動態の差異に起因する造血幹細胞のサイトカイン応答パラドックス
2022 - 2024 造血幹細胞のサイトカイン応答を規定するクロマチン動態変化の制御
2018 - 2023 Self-renewal capacity of hematopoietic stem cells and mitochondrial metabolism

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Papers (45)：

Wenjuan Ma, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Ahad Khalilnezhad, Miho Kataoka, Yuichiro Arima, Yosuke Tanaka, Shigeru Yanagi, Terumasa Umemoto, Toshio Suda. MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response. The EMBO Journal. 2024. 43. 3. 339-361
Wenjuan Ma, Yuichiro Arima, Terumasa Umemoto, Tomomasa Yokomizo, Yuqing Xu, Kenichi Miharada, Yosuke Tanaka, Toshio Suda. Metabolic regulation in erythroid differentiation by systemic ketogenesis in fasted mice. Experimental hematology. 2023
Xichen Hu, Tadahito Yasuda, Noriko Yasuda-Yosihara, Atsuko Yonemura, Terumasa Umemoto, Yutaka Nakachi, Kohei Yamashita, Takashi Semba, Kota Arima, Tomoyuki Uchihara, et al. Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion. JHEP Reports. 2023. 100892-100892
Takahiko Akiyama, Tadahito Yasuda, Tomoyuki Uchihara, Noriko Yasuda-Yoshihara, Benjy J Y Tan, Atsuko Yonemura, Takashi Semba, Juntaro Yamasaki, Yoshihiro Komohara, Koji Ohnishi, et al. Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors. Cancer research. 2022. 83. 5. 753-770
Yuji Takihara, Takumi Higaki, Tomomasa Yokomizo, Terumasa Umemoto, Kazunori Ariyoshi, Michihiro Hashimoto, Maiko Sezaki, Hitoshi Takizawa, Toshihiro Inoue, Toshio Suda, et al. Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells. Communications Biology. 2022. 5. 1

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MISC (8)：

横溝智雅, 渡邊直紀, 梅本晃正, 高久智生, 須田年生, 黒川峰夫, 小松則夫, 大里元美. マウス胎生期における造血幹細胞の成熟はEvi-1/Hlf軸によって制御される(Evi-1/Hlf axis regulates HSC maturation in the mouse embryo). 臨床血液. 2018. 59. 9. 1571-1571
Ayako Nakamura-Ishizu, Takayoshi Matsumura, Terumasa Umemoto, A'Qilah Abdul Majeed, Toshio Suda. RAPID AND DIRECT MEGAKARYOCYTE-LINEAGE DIFFERENTIATION FROM HSCS HALLMARK HEMATOPOIETIC SYSTEM RESPONSE TO STRESS. EXPERIMENTAL HEMATOLOGY. 2016. 44. 9. S91-S91
S. Kozakai, T. Umemoto, M. Yamato, M. Umezu, T. Okano. Functional analysis of the transcription factors specifically expressed in hematopoietic stem cells. MOLECULAR BIOLOGY OF THE CELL. 2014. 25
Salama Yousef, Nishida Chiemi, Gritli Ismael, Umemoto Terumasa, Nakauchi Hiromitsu, Hattori Koichi, Heissig Beate. EGFL7は骨髄中の微小環境における造血幹/前駆細胞の運命をβ3インテグリンを介して制御する(EGFL7 regulates hematopoietic stem/progenitor cell fate in the bone marrow niche through β3 integrin). 臨床血液. 2014. 55. 9. 1352-1352
T. Yoshida, T. Iwata, T. Umemoto, Y. Shiratsuchi, N. Kawashima, T. Sugiyama, M. Yamato, T. Okano. Lgr5 mediated integrin signaling promotes the proliferation of dental epithelial progenitor cells. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2012. 6. 11-11

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Professional career (1)：

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