Kono Keiko

Kono Keiko | Kono Keiko

Affiliation and department：
Job title：准教授

Research field (2)： Cell biology , Medical biochemistry

Research keywords (5)： Plasma membrane damage , 細胞周期チェックポイント , 細胞老化 , アクチン , 細胞質分裂

Research theme for competitive and other funds (10)：

2024 - 2029 細胞膜損傷による細胞老化の分子基盤と個体老化への寄与の理解
2020 - 2024 Molecular mechanisms and in vivo significance of the plasma membrane damage-dependent cellular senescence
2021 - 2024 Immune cell-like functions of epithelial cells induced by MHC-I signal
2019 - 2022 Whole body analysis of plasma membrane damage induced cellular senescence
2016 - 2021 細胞老化の鍵を握る脂質新機能の光操作による解明

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Papers (24)：

Aisulu Maipas, Atsuko Sato, Yohsuke Moriyama, Tadashi Yamamoto, Keiko Kono. Knockdown of CNOT3, a subunit of the CCR4-NOT deadenylase complex, sensitizes A549 human non-small cell lung cancer cells to senescence-inducing stimuli. Biochemical and biophysical research communications. 2025. 748. 151294-151294
Taisuke Seike, Hiroki Takekata, Keiko Kono, Natsue Sakata, Hazuki Kotani, Chikara Furusawa, Fumio Matsuda. Discovery and identification of a novel yeast species, Hanseniaspora drosophilae sp. nov., from Drosophila in Okinawa, Japan. International journal of systematic and evolutionary microbiology. 2025. 75. 2
Shinju Sugiyama, Keiko Kono. Exocytic plasma membrane flows remodel endoplasmic reticulum-plasma membrane tethering for septin collar assembly. Science advances. 2024. 10. 11. eadj1512
Kojiro Suda, Yohsuke Moriyama, Nurhanani Razali, Yatzu Chiu, Yumiko Masukagami, Koutarou Nishimura, Hunter Barbee, Hiroshi Takase, Shinju Sugiyama, Yuta Yamazaki, et al. Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts. Nature aging. 2024. 4. 3. 319-335
Shinju Sugiyama, Kojiro Suda, Keiko Kono. Cytoplasmic zoning by protein phase transition after membrane permeabilization. Journal of biochemistry. 2024. 175. 2. 147-153

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MISC (4)：

河野恵子, 西村耕太郎, 城村由和, 中西真. アクチン・フォルミン・ミオシンと細胞個体機能とのメカニカルなつながり細胞膜張力制御と染色体分配(Down-regulating cortical tension ensures timely chromosome segregation). 日本細胞生物学会大会講演要旨集. 2021. 73回. S8-2
河野恵子, 西村耕太郎, 城村由和, 中西真. フォルミンおよびミオシンと生命機能とのメカニカルなつながり細胞膜張力制御と染色体分配(Down-regulating cortical tension ensures timely chromosome segregation). 日本細胞生物学会大会講演要旨集. 2020. 72回. S3-1
河野恵子, 西村耕太郎, 城村由和, 出口確, JIANG Zixian, 内田和彦, 鈴木成実, 嶋田緑, 千葉祥恵, 広田亨, et al. Down-regulating cortical tension ensures timely chromosome segregation. 日本癌学会学術総会抄録集(Web). 2019. 78th
西村耕太郎, 城村由和, 島田緑, 千葉祥恵, 河野恵子, 中西真. CDKによるフォーミンDIAPH1とプロフィリンPFN1の乖離は分裂期球形化の終了に重要である. 日本分子生物学会年会プログラム・要旨集(Web). 2016. 39th

Books (1)：

Education (3)：

2002 - 2005 The University of Tokyo Graduate School of Frontier Sciences
2000 - 2002 University of Tokyo Graduate School of Frontier Sciences
1996 - 2000 The University of Tokyo Faculty of Science Department of Biological Sciences

Professional career (1)：

Work history (5)：

2025/04 - 現在 Okinawa Institute of Science and Technology Graduate University Membranology Unit Associate Professor
2017/12 - 2025/03 Okinawa Institute of Science and Technology Graduate University Membranology Unit Assistant Professor
2012/04 - 2017/12 Nagoya City University Graduate School of Medical Sciences Department of Cell Biology Lecturer
2005/09 - 2012/03 Postdoc, Dana-Farber Cancer Institute, Harvard Medical School
2005/04 - 2005/08 Teaching assistant, University of Tokyo

Awards (1)：

Association Membership(s) (5)：

American Society of Cell Biology , 酵母遺伝学フォーラム , 日本分子生物学会 , 日本癌学会 , THE JAPANESE BIOCHEMICAL SOCIETY

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