MOTOMI OSATO

オオサトモトミ | MOTOMI OSATO

Affiliation and department：
Homepage URL (1)： http://ircms.kumamoto-u.ac.jp/research/motomi_osato/

Research field (2)： Hematology and oncology , Tumor biology

Research keywords (14)： LINE-1 , phase separation , telomere , Down's syndrome , Aging , Animal model , Retroelements , Non-coding genome , Hematology , Runx , Transcription factor , Enhancer , Hematopoietic stem cell , Leukemia

Research theme for competitive and other funds (8)：

2023 - 2026 新たな膵再生医療の構築に向けたeR1活性細胞の幹細胞機能の解析
2022 - 2025 Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategy
2019 - 2022 Development of novel antibodies against leukemia and elucidation of their blocking mechanisms
2018 - 2021 multi-pathogenesis aging research based on the Down syndrome aneuploidy model
2017 - 2020 HOX関連白血病における15-PGDHによる白血病幹細胞制御機構の解明

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Papers (148)：

Miwa Tanaka, Mizuki Homme, Yasuyo Teramura, Kohei Kumegawa, Yukari Yamazaki, Kyoko Yamashita, Motomi Osato, Reo Maruyama, Takuro Nakamura. HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice. JCI insight. 2023. 8. 10
Mohamed Gaber Abdallah, Vania Swee Imm Teoh, Bibek Dutta, Tomomasa Yokomizo, Motomi Osato. Childhood hematopoietic stem cells constitute the permissive window for RUNX1-ETO leukemogenesis. International journal of hematology. 2023
Mingrui Guo, Hon Man Tim Chan, Qi-Ling Zhou, Omer An, Ying Li, Yangyang Song, Zi Hui Tan, Hui En Vanessa Ng, Philomina Sona Peramangalam, Zhi Qing Tan, et al. Core binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis. Blood. 2023. 141. 25. 3078-3090
Cheng-Yong Tham, LaiFong Poon, TingDong Yan, Javier Yu Peng Koh, Muhammad Khairul Ramlee, Vania Swee Imm Teoh, Suihan Zhang, Yi Cai, Zebin Hong, Gina S Lee, et al. High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform. Nature communications. 2023. 14. 1. 281-281
Bibek Dutta, Motomi Osato. The RUNX Family, a Novel Multifaceted Guardian of the Genome. Cells. 2023. 12. 2

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MISC (94)：

荒木愛, 清野麻衣, 古賀沙緒里, 大里元美, 小川峰太郎. マウス胎仔における造血性内皮細胞の同定と造血幹細胞への分化誘導. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
Mon Naing Naing, Matsuo Junichi, 山村明寛, 大里元美, Ito Yoshiaki. Precancerous state induced by knockout of Runx1 and Runx3 in mammary stem cells(和訳中). 日本癌学会総会記事. 2019. 78回. E-2018
指田吾郎, 横溝貴子, 久保田翔, 原田浩徳, 大里元美, 岩間厚志. Tet2欠損によるHmga2機能制御と骨髄異形成症候群発症の分子基盤(Tet2 loss reshapes Hmga2 binding regions to promote the development of myelodysplastic syndrome). 日本癌学会総会記事. 2019. 78回. E-2077
Matsuo Junichi, Mon Naing Naing, Dochi Daisuke, 山村明寛, 大里元美, Ito Yoshiaki. Ras-Erk pathway regulates normal and cancer stem cell in stomach(和訳中). 日本癌学会総会記事. 2019. 78回. E-2089
横溝貴子, 久保田翔, 岩間厚志, 原田浩徳, 大里元美, 指田吾郎. RUNX3発現による骨髄異形成症候群発症の分子基盤解明(RUNX3 over-expression impedes RUNX1 function and promotes the development of myelodysplastic syndrome). 日本癌学会総会記事. 2019. 78回. P-2224

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Lectures and oral presentations (19)：

造血幹細胞特異的遺伝子操作を可能とするRunx1 enhancer-CreERT2トランスジェニックマウス(Runx1 enhancer-CreERT2 transgenic mice for hematopoietic stem cells-specific gene targeting, imaging and transgenesis)
(日本癌学会総会記事 2014)
世界で活躍するがん研究者の視点 Runxファミリー遺伝子と発がん機構(Challenging cancer research from international frontier Runx family genes and tumorigenesis)
(日本癌学会総会記事 2012)
Runx1/AML1不全は造血幹細胞/前駆細胞において発癌性Rasの誘導する細胞老化、アポトーシスおよび分化を抑制する(Runx1/AML1 insufficiency attenuates oncogenic RAS-induced senescence, apoptosis and differentiation in hematopoietic stem/progenitor cells)
(日本癌学会総会記事 2006)
RUNX1/AML1の増量投与は骨髄性白血病の発生を促進する DS-AMKL(ダウン症関連急性巨核芽球性白血病)の意味(An increased dose of RUNX1/AML1 promotes the development of myeloid leukemia: implications for DS-AMKL)
(日本癌学会総会記事 2004)
家族性白血病FPD/AMLマウスモデル系の作成
(日本癌学会総会記事 2001)

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Education (2)：

1993 - 1997 Kumamoto Univeristy Graduate School of Medicine
1984 - 1990 Oita Medical University

Professional career (1)：

医学博士 (熊本大学)

Work history (5)：

2015/04 - 現在 Kumamoto University International Research Center for Medical Sciences Professor
2008/10 - 2022/12 National University of Singapore Cancer Science Institute Associate Professor
2002/04 - 2008/09 Institute of Molecular and Cell Biology (Singapore) Assistant Professor
1997/04 - 2002/03 Kyoto University Institute for Virus Research Research Fellow
1990/04 - 1993/03 Kumamoto University Hospital Clinical Fellow

Committee career (2)：

2012 - 現在 Gene Associate Editor
2012 - 現在 Gene 編集委員

Association Membership(s) (4)：

Molecular Biology Society of Japan , AMERICAN SOCIETY OF HEMATOLOGY , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY OF HEMATOLOGY

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