Takahashi Tatsuro

タカハシタツロウ | Takahashi Tatsuro

Research field (2)： Molecular biology , Genetics

Research keywords (27)： Homologous recombination , DNA修復 , 染色体分配 , DNA複製 , 無細胞系 , ツメガエル , ミスマッチ修復 , コヒーシン , ツメガエル卵抽出液 , 染色体 , 染色体接着 , 姉妹染色体接着 , Cdc7 kinase , 細胞周期 , クロマチン , ゲノム安定性 , 突然変異 , HP1 , タンパク質アセチル化 , Scc2-Scc4 , DNA 損傷・修復 , ツメガエル卵無細胞系 , クロマチン形成 , アフリカツメガエル , 染色体複製 , DNA組換え , 分裂酵母

Research theme for competitive and other funds (29)：

2024 - 2029 Elucidating the fundamental structures and operational principles of chromatin that define the epicode
2022 - 2024 塩基ミスマッチを起点とするゲノム複製正確性維持反応と非ゲノム情報の機能的相関
2020 - 2024 DNA複製と相同性依存的修復の正確性維持機構を統御する反応の解明
2021 - 2023 相同組換えの正確性を保証するメカニズムの理解
2020 - 2022 損傷チェックポイント機構によるDNA二重鎖切断修復の正確性制御メカニズム

2020 - 2022 ゲノム情報の複製正確性維持機構と非ゲノム情報維持反応のクロストークの解明

2021 - 2022 正確な相同性依存的修復の試験管内再構成系による理解

2018 - 2020 相同性依存的修復の品質管理機構を次世代シーケンス技術を用いて探る

2017 - 2020 ミスマッチ修復システムによる相同組換え品質保証機構の動作原理の解明

2017 - 2018 The quality-control mechanism of homologous recombination by the DNA mismatch repair system

2017 - 2018 The quality-control mechanism of genome inheritance by the mismatch repair system

2016 - 2018 A unified understanding of replication error correction and antirecombination mediated by the mismatch repair system

2016 - 2017 Molecular mechanisms of the suppression of mutations and cancer by the mismatch repair reaction in the context of chromatin

2014 - 2017 In vitro analysis of chromosome cohesion and DNA double-strand break repair mediated by cohesin

2013 - 2017 In vitro analysis of functions of cohesin in replication-coupled sister-chromatid cohesion and DNA double-strand break repair

2013 - 2015 タンパク質アセチル化を介したゲノム伝達・維持・再編機構の新規手法による解析

2013 - 2015 ミスマッチ修復がクロマチン複製と協調して機能する機構の解析

2013 - 2015 Identification of factors involved in the eukaryotic mismatch repair reaction

2011 - 2013 DNA複製・クロマチン形成とミスマッチ修復機構の機能的カップリング

2011 - 2013 Chromatin regulation by DNA replication and recombination

2011 - 2012 Molecular mechanism of eukaryotic DNA mismatch repair

2011 - 2012 Novel interplay between chromatin assembly and DNA mismatch repair

2011 - 2012 Reactions required for eukaryotic mismatch repair to function in the context of chromatin

2010 - 2011 新規試験管内モデル系を用いた姉妹染色体接着反応の分子機構の解析

2009 - 2010 Involvement of the Cdc7 protein kinse in sister chromatid cohesion

2008 - 2009 Molecular mechanism of chromatin association of the Scc2-Scc4 cohesin loading complex

2007 - 2008 Functional analysis of heterochromatin protein 1 in sister chromatid cohesion

2007 - 2008 Involvement of HP1 in establishment of sister chromatid cohesion in higher eukaryotes

2007 - 2008 Roles of Xenopus HP1 for sister chromatid cohesion

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Papers (42)：

Kensuke Tatsukawa, Reihi Sakamoto, Yoshitaka Kawasoe, Yumiko Kubota, Toshiki Tsurimoto, Tatsuro S Takahashi, Eiji Ohashi. Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts. Nucleic acids research. 2024
Yoshitaka Kawasoe, Sakiko Shimokawa, Peter J Gillespie, J Julian Blow, Toshiki Tsurimoto, Tatsuro S Takahashi. The Atad5 RFC-like complex is the major unloader of proliferating cell nuclear antigen in Xenopus egg extracts. The Journal of biological chemistry. 2024. 300. 1. 105588-105588
Ryota Miyashita, Atsuya Nishiyama, Weihua Qin, Yoshie Chiba, Satomi Kori, Norie Kato, Chieko Konishi, Soichiro Kumamoto, Hiroko Kozuka-Hata, Masaaki Oyama, et al. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. eLife. 2023. 12. e79013
Robert P Fuchs, Asako Isogawa, Joao A Paulo, Kazumitsu Onizuka, Tatsuro Takahashi, Ravindra Amunugama, Julien P Duxin, Shingo Fujii. Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide. eLife. 2021. 10
Mathew J K Jones, Camille Gelot, Stephanie Munk, Amnon Koren, Yoshitaka Kawasoe, Kelly A George, Ruth E Santos, Jesper V Olsen, Steven A McCarroll, Mark G Frattini, et al. Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Molecular Cell. 2021. 81. 3. 426-441

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MISC (24)：

達川絢介, 高橋達郎, 大橋英治. 9-1-1 and MRN redundantly promote the resection and monitoring of DNA double-strand breaks. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
達川絢介, 高橋達郎, 大橋英治. 9-1-1 and MRN independently promote DSB end resection. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
達川絢介, 釣本敏樹, 高橋達郎, 大橋英治. チェックポイントセンサー9-1-1とMRNによる二重鎖切断後の損傷応答制御. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
小川志帆, 半田哲也, 城戸沙友里, 中村優太, 小川英知, 浅川東彦, 高橋達郎, 高橋達郎, 中川拓郎, 平岡泰, et al. テロメア結合タンパク質およびシェルタリン構成因子によるDNA複製の時空間的制御機構の解明. 日本生化学会大会(Web). 2017. 90th
Takuro Nakagawa, Atsushi Onaka, Tatsuro S. Takahashi, Hisao Masukata. Rad51 and Rad54 promote noncrossover recombination between centromere repeats to prevent isochromosome formation. GENES & GENETIC SYSTEMS. 2016. 91. 6. 372-372

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Work history (3)：

2020/12 - 現在 Kyushu University Faculty of Science Professor
2016/10 - 現在 Kyushu University Faculty of Science Associate professor
2011 - 2016/09 大阪大学理学(系)研究科(研究院) 助教

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