Research field (6)：
Biomaterials
, Biomedical engineering
, Hematology and oncology
, Hematology and oncology
, Hematology and oncology
, Hematology and oncology
Research keywords (3)：
regenerative medicine
, immunology
, hematology
Research theme for competitive and other funds (3)：
2021 - 2026 Elucidating the fundamental mechanism of platelet biogenesis and its medical application
2021 - 2024 Elucidation of the NK cell immune escape mechanism using iPS cell-derived platelets and development of treatment
2015 - 2019 The role of the nucleic acid sensor molecule DHX29 in hematopoietic cell immune responses and hematopoietic tumors
Papers (42)：
Si Jing Chen, Kazuya Hashimoto, Kosuke Fujio, Karin Hayashi, Sudip Kumar Paul, Akinori Yuzuriha, Wei-Yin Qiu, Emiri Nakamura, Maria Alejandra Kanashiro, Mio Kabata, et al. A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility. Nature Communications. 2024. 15. 1
Charlotte Flahou, Tatsuya Morishima, Natsumi Higashi, Yoshikazu Hayashi, Huaigeng Xu, Bo Wang, Chaoqi Zhang, Atsushi Ninomiya, Wei-Yin Qiu, Akinori Yuzuriha, et al. Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells. Biochemical and biophysical research communications. 2023. 662. 76-83
Naoshi Sugimoto, Sou Nakamura, Shin Shimizu, Akiko Shigemasa, Junya Kanda, Nobuki Matsuyama, Mitsunobu Tanaka, Tomoya Hayashi, Akihiro Fuchizaki, Masayuki Nogawa, et al. Production and nonclinical evaluation of an autologous iPSC-derived platelet product for the iPLAT1 clinical trial. Blood advances. 2022. 6. 23. 6056-6069
Naoshi Sugimoto, Junya Kanda, Sou Nakamura, Toshiyuki Kitano, Masakatsu Hishizawa, Tadakazu Kondo, Shin Shimizu, Akiko Shigemasa, Hideyo Hirai, Yasuyuki Arai, et al. iPLAT1: The first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study. Blood. 2022. 140. 22. 2398-2402
Masamitsu Sone, Sou Nakamura, Sachiko Umeda, Harumi Ginya, Motohiko Oshima, Maria Alejandra Kanashiro, Sudip Kumar Paul, Kanae Hashimoto, Emiri Nakamura, Yasuo Harada, et al. Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs. Stem Cell Reports. 2021. 16. 12. 2861-2870
