2019 - 2022 Research of disease modeling and drug discovery through the maturation regulation of human iPS cell-derived cardiac tissue recapitulating human heart function
2019 - 2022 Research for the identification of biomarkers regarding the progression of cardiomyopathy based on imaging mass spectrometry and the therapeutic approach
2019 - 2022 Development of efficient organ protection during deep hypothermic circulatory arrest based on "artificial hibernation"
2018 - 2021 Development of a method of functional integration between host and graft on the transplantation therapy of human iPS cell-derived cardiac tissues
2017 - 2020 Development of self-growing vascular graft using decellularized vascular tissue and human iPS cell-derived vascular cells
2016 - 2019 Development of cardiomyopathy-specific iPS cell-derived 3-dimensional biomaterial-based cardiac tissues suitable for drug discovery
2016 - 2019 Research for prevention of complications in cardiovascular surgeries through regulating HMGB1
2016 - 2019 Development of the regulation of inflammation in the field of cardiovascular surgery using human iPS cell-derived mesenchymal stem cells
2015 - 2018 Development of a new vascular regenerative therapy for severe limb ischemia by the transplantation of human iPS cell-derived vascular cells
2015 - 2018 Development of human iPS cell-derived multidisciplinary thick viable organized tissues aiming for myocardial regenerative therapy
2015 - 2018 Investigation for the attenuation of arrhythmia related to human iPS cell-based cardiac regenerative therapy
2013 - 2016 Drug discovery for the treatment of severe heart failure
2013 - 2016 ヒトiPS細胞由来間葉系細胞による心臓外科領域の全身炎症反応制御法の開発
2013 - 2014 多能性幹細胞による心筋再生治療実現のための集学的多層組織化移植片の構築
Show all
Papers (66)：
Kozue Murata, Akiko Makino, Keizo Tomonaga, Hidetoshi Masumoto. Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model. iScience. 2024. 27. 1. 108641-108641
Daisuke Heima, Masafumi Takeda, Yasuhiko Tabata, Kenji Minatoya, Jun K Yamashita, Hidetoshi Masumoto. Therapeutic potential of human induced pluripotent stem cell-derived cardiac tissue in an ischemic model with unloaded condition mimicking left ventricular assist device. The Journal of thoracic and cardiovascular surgery. 2023
Wen-Jin Ho, Mako Kobayashi, Kozue Murata, Yoshihide Hashimoto, Kenji Izumi, Tsuyoshi Kimura, Hideo Kanemitsu, Kazuhiro Yamazaki, Tadashi Ikeda, Kenji Minatoya, et al. A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture. Scientific Reports. 2022. 12. 1
Shoichi Kyo, Kozue Murata, Masahide Kawatou, Kenji Minatoya, Genshiro A Sunagawa, Hidetoshi Masumoto. Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest. JTCVS open. 2022. 12. 201-210
Yasushi Konegawa, Toshie Kuwahara, Jun-Ichiro Jo, Kozue Murata, Takahide Takeda, Tadashi Ikeda, Kenji Minatoya, Hidetoshi Masumoto, Yasuhiko Tabata. Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2022
