Niimi Atsuko

ニイミアツコ | Niimi Atsuko

Affiliation and department：

Research field (1)： Tumor biology

Research keywords (5)： PCNA , DNAポリメラーゼ , 発がん , DNA複製 , DNA修復

Research theme for competitive and other funds (5)：

2022 - 2025 Fork Reversal因子POLD4を指標とした新規肺癌分子標的治療法の開発
2018 - 2022 Analysis of gene module for genomic instability in lung cancer
2018 - 2022 Targeting ceramide synthase 6–dependent metastasis-prone phenotype in lung cancer cells
2015 - 2018 Analysis of individual fate determination of irradiated cells by using live cell imaging technique
2015 - 2018 Proof of mutual interference between two DNA double strand break sites leading to chromosomal translocation

Papers (36)：

Atsuko Niimi, Siripan Limsirichaikul, Keiko Kano, Yasuyoshi Mizutani, Toshiyuki Takeuchi, Patinya Sawangsri, Dat Quoc Tran, Yoshiyuki Kawamoto, Motoshi Suzuki. LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration. Cancers. 2023. 15. 10. 2781-2781
Yasuyoshi Mizutani, Kazuya Shiogama, Ken-Ichi Inada, Toshiyuki Takeuchi, Atsuko Niimi, Motoshi Suzuki, Yutaka Tsutsumi. Enzyme-labeled Antigen Method: Factors Influencing the Deterioration of Antigen-binding Activity of Specific Antibodies during Formalin Fixation and Paraffin Embedding. Acta histochemica et cytochemica. 2022. 55. 5. 129-148
Masanobu Saruta, Kiyoshi Takahara, Atsuhiko Yoshizawa, Atsuko Niimi, Toshiyuki Takeuchi, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, et al. Alanine-Serine-Cysteine Transporter 2 Inhibition Suppresses Prostate Cancer Cell Growth In Vitro. Journal of clinical medicine. 2022. 11. 18
Yasuhiro Kondo, Shunsuke Watanabe, Atsuki Naoe, Toshiyuki Takeuchi, Atsuko Niimi, Motoshi Suzuki, Naoya Asai, Seiji Okada, Tomonori Tsuchiya, Mika Murayama, et al. Antitumor effect of polyphyllin D on liver metastases of neuroblastoma. Pediatric surgery international. 2022. 38. 8. 1157-1163
Hanxiao Shi, Atsuko Niimi, Toshiyuki Takeuchi, Kazuya Shiogama, Yasuyoshi Mizutani, Taisuke Kajino, Kenichi Inada, Tetsunari Hase, Takahiro Hatta, Hirofumi Shibata, et al. CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation. Cancer science. 2021. 112. 7. 2770-2780

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MISC (17)：

水谷泰嘉, 竹内俊幸, LIMSIRICHAIKUL Siripan, 新美敦子, SAWANGSRI Patinya, TRAN Dat Q., 塩竈和也, 杉原英志, 奥野友介, 原範子, et al. Analysis of a lung cancer patient-derived xenograft revealed a highly metastatic property with KRAS allelic imbalance. 日本癌学会学術総会抄録集(Web). 2024. 83rd
柴田淳史, 佐藤浩央, 新美敦子, 安原崇哲, 萩原慶彦, Permata Tiara, 磯野真由, Nuryadi Endang, 尾池貴洋, 吉本由哉, et al. ゲノム恒常性維持機構の破綻と疾患発症の分子メカニズム DNA二本鎖切断修復経路による免疫チェックポイント標的分子PD-L1の発現制御機構. 生命科学系学会合同年次大会. 2017. 2017年度. [3PW02-6]
新美敦子, 萩原慶彦, リムシリチャイクル・シリパン, 尾池貴洋, 佐藤浩央, 中野隆史, 柴田淳史. 重粒子線に特徴的なDNA損傷の可視化と細胞運命決定に与える影響の解析. 生命科学系学会合同年次大会. 2017. 2017年度. [4P2T14-0597)]
柴田淳史, 佐藤浩央, 新美敦子, 安原崇哲, 萩原慶彦, パーマタ・ティアラ, 磯野真由, ナーヤディ・エンダング, 尾池貴洋, 吉本由哉, et al. 放射線照射により誘導される免疫チェックポイント標的分子PD-L1の発現制御機構. 日本放射線影響学会大会講演要旨集. 2017. 60回. 116-116
新美敦子, 萩原慶彦, リムシリチャイクル・シリパン, 尾池貴洋, 佐藤浩央, 中野隆史, 柴田淳史. 超解像度顕微鏡による重粒子線誘発クラスターDNA二本鎖切断の空間分布解析. 日本放射線影響学会大会講演要旨集. 2017. 60回. 156-156

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Lectures and oral presentations (25)：

POLD4-PRIMPOL経路を標的とした新規非小細胞肺癌治療法の検討
(名古屋大学環境医学研究所基盤医学特論 2025)
Targeting the POLD4-PRIMPOL axis in non-small cell lung cancer
(2024)
POLD4-PRIMPOL経路を標的とした新規非小細胞肺がん治療法の検討
(2023)
Targeting the POLD4-PRIMPOL pathway in non-small cell lung cancer
(2023)
POLD4-dependent DDR pathway may be targeted in non-small cell lung cancer
(2022)

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Professional career (1)：

Agriculture (Tohoku University)

Work history (2)：

2018/04 - 現在 Fujita Health University
2014/10 - 2018/03 Gunma University Initiative for Advanced Research, Division of Integrated Oncology Research

Association Membership(s) (3)：

THE JAPANESE CANCER ASSOCIATION , THE JAPANESE RADIATION RESEARCH SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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