Research keywords (3)：
Post-translational modification
, Imaging mass spectrometry
, C. elegans
Research theme for competitive and other funds (6)：
2016 - 2019 Lipid mapping on single-cell level by imaging mass spectrometry (IMS)
2013 - 2016 Application of TOF-SIMS imaging to C. elgans
2013 - 2016 Metabolomic analysis of blood cells by single-cell imaging mass spectrometry.
2002 - 2003 Phosphoiylation -dependent regulation of alternative splicing
2002 - 2002 Biobjeによる遺伝子発現シミュレーションの線虫個体への応用
1997 - 1998 Network formation of motoneurons
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Papers (13)：
Kimura Y, Tsutsumi K, Konno A, Ikegami K, Hameed S, Kaneko T, Kaplan OI, Teramoto T, Fujiwara M, Ishihara T, et al. Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway. Sci Rep. 2018. 8. 1. 8392-8392
Saira Hameed, Yuki Sugiura, Yoshishige Kimura, Kalmesh Kumar Shrivas, Mitsutoshi Setou. Nanoparticle-assisted laser desorption/ionization (nano- PALDI)-based imaging mass spectrometry (IMS) and its application to brain sciences. Nanomedicine and the Nervous System. 2012. 97-118
木村 芳滋, 杉浦 悠毅, 早坂 孝宏, 瀬藤 光利. 脂質とステロイドのin vivoでの機能 無脊椎動物モデル生体からのアプローチ イメージング質量分析(IMS) C.elegansにおける脂質の空間的分布を可視化する新しいイメージングツール(Functions of lipids and steroids in vivo: approaches from invertebrate model organisms Imaging mass spectrometry (IMS): A novel imaging tool to visualize the spatial distribution of lipids in C. elegans). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010. 83回・33回. 1W19-2
堤 弘次, 久保 亜紀子, 高木 博, 赤津 裕康, 紺野 在, 宮本 裕子, 矢尾 育子, 江川 潔, 佐藤 尚武, 久保 亮治, et al. 多系統萎縮症患者脳ではγ-tubulinが減少しており、人工的γ-tubulin 2減少モデル動物は多系統萎縮症様の神経変性と運動失調を発症する(γ-Tubulins are decreased in the MSA patient brains and γ-tubulin 2-deficient mouse displays MSA-like neurodegeneration and ataxia). 神経化学. 2011. 50. 2-3. 163-163
Yoshishige Kimura, Oktay Kaplan, Saira Hameed, Hirofumi Kunitomo, Yuichi Iino, Oliver Blacque, Mitsutoshi Setou. Ciliated sensory neurons of C. elegans are regulated by tubulin polyglutamylation in response to the environmental stresses. NEUROSCIENCE RESEARCH. 2011. 71. E47-E47
木村 芳滋, 倉部 誠也, 池上 浩司, 堤 弘次, 小西 慶幸, Kaplan Oktay I, 國友 博文, 飯野 雄一, Blacque Oliver E, 瀬藤 光利. チューブリンのポリグルタミン酸化修飾は双方向性に制御され、線虫(C.elegans)の知覚行動に必要である(Tubulin polyglutamylation is regulated by a bidirectional enzymatic system and is required for sensory behaviors of C. elegans). 神経化学. 2010. 49. 2-3. 479-479
Yoshishige Kimura, Nobuya Kurabe, Koji Ikegami, Koji Tsutsumi, Yoshiyuki Konishi, Oktay I. Kaplan, Hirofumi Kunitomo, Yuichi Iino, Oliver E. Blacque, Mitsutoshi Setou. Tubulin polyglutamylation is regulated by a bidirectional enzymatic system and is required for sensory behaviors of C. elegans. NEUROSCIENCE RESEARCH. 2010. 68. E58-E58
Chihiro Murayama, Yoshishige Kimura, Mitsutoshi Setou. Imaging mass spectrometry: Principle and application. Biophysical Reviews. 2009. 1. 3. 131-139
