Rchr
J-GLOBAL ID:201601019377497836   Update date: Apr. 22, 2021

Taishi Nakamura

ナカムラ タイシ | Taishi Nakamura
Affiliation and department:
Job title: 准教授
Research field  (4): Cardiology ,  Biological, health, and medical informatics ,  Pharmacology ,  Molecular biochemistry
Research keywords  (4): IoT ,  心不全 ,  高血圧 ,  食塩感受性
Research theme for competitive and other funds  (20):
  • 2019 - 2022 Staple核酸を用いた新規核酸医薬開発
  • 2020 - 2021 The role of PKG in salt sensitivity and the excitatory synapse through activation in sympathetic nervous system
  • 2020 - 2021 iPad問診票を用いた患者情報の入力と連携
  • 2017 - 2020 PKG1αロイシンジッパーを介した動態制御の解明と心不全治療の応用
  • 2018 - 2019 Pepper for Biz の導入及び有効活用について
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Papers (76):
  • Hiroki Usuku, Eiichiro Yamamoto, Momoko Noguchi, Takashi Komorita, Masafumi Takae, Fumi Oike, Kenshi Yamanaga, Miwa Ito, Koichiro Fujisue, Daisuke Sueta, et al. Elevated C-reactive protein is significantly associated with left ventricular dysfunction in patients with aortic regurgitation and concomitant collagen disease. International journal of cardiology. 2021. 328. 152-157
  • Taiki Nishihara, Eiichiro Yamamoto, Daisuke Sueta, Koichiro Fujisue, Hiroki Usuku, Fumi Oike, Masafumi Takae, Noriaki Tabata, Miwa Ito, Kenshi Yamanaga, et al. Impact of Reactive Oxidative Metabolites Among New Categories of Nonischemic Heart Failure. Journal of the American Heart Association. 2021. e016765
  • Yuichi Kimura, Yasuhiro Izumiya, Satoshi Araki, Satoru Yamamura, Shinsuke Hanatani, Yoshiro Onoue, Toshifumi Ishida, Yuichiro Arima, Taishi Nakamura, Eiichiro Yamamoto, et al. Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation. Circulation journal : official journal of the Japanese Circulation Society. 2021
  • Nobuhiro Nakanishi, Koichi Kaikita, Masanobu Ishii, Naoto Kuyama, Noriaki Tabata, Miwa Ito, Kenshi Yamanaga, Koichiro Fujisue, Tadashi Hoshiyama, Hisanori Kanazawa, et al. Development and assessment of total thrombus-formation analysis system-based bleeding risk model in patients undergoing percutaneous coronary intervention. International Journal of Cardiology. 2021. 325. 121-126
  • Nobuhiro Nakanishi, Koichi Kaikita, Masanobu Ishii, Naoto Kuyama, Noriaki Tabata, Miwa Ito, Kenshi Yamanaga, Koichiro Fujisue, Tadashi Hoshiyama, Hisanori Kanazawa, et al. Hemodialysis-related low thrombogenicity measured by total thrombus-formation analysis system in patients undergoing percutaneous coronary intervention. Thrombosis research. 2021. 200. 141-148
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MISC (93):
Patents (1):
  • 新規TRPC6発現抑制法の開発
Books (1):
  • 心不全(第2版)上
    日本臨牀 2018
Lectures and oral presentations  (20):
  • Cyclic GMP Compartmentalization and the Differential PKG Signaling to Counter Pathological Cardiac Remodeling
    (2021)
  • Current understanding of molecular pathophysiology in HFpEF
    (The 24th Annual Scientific Meeting of the Japanese Heart Failure Society 2020)
  • Oxidation of Cyclic GMP-dependent Protein Kinase-1α (PKG) Phosphorylates Tyrosine Hydroxylase and Induces Salt Sensitive Hypertension through Sympathetic Nervous Activation
  • Single Cysteine Redox Sensor in PKG1α Controls Salt Sensitivity through Renal Sympathetic Nerve Activity
    (JCS-APSC 2020)
  • プロテインキナーゼG(PKG) 1αのジスルフィド二量体化の予防は、腎交感神経を介して食塩感受性を緩和し心腎血管連関における有用な治療戦略である
    (第42回日本高血圧学会(東京) SHR賞セッション 2019)
more...
Professional career (1):
  • 博士(医学) (熊本大学大学院医学教育部)
Work history (5):
  • 2018/02 - 現在 Kumamoto University University Hospital
  • 2016/04 - 2018/01 Kumamoto University University Hospital
  • 2015/11 - 2016/03 Kumamoto University University Hospital
  • 2010/10 - 2015/08 ジョンズ・ホプキンス大学医学研究所 博士研究員
  • 2010/04 - 2010/09 Kumamoto University Graduate School of Medical Sciences Department of Pharmacology and Molecular Therapeutics
Awards (5):
  • 2015/05 - The 6th Annual Johns Hopkins Cardiovascular Research Retreat Oral Presentation Award (Basic Science) PKG1α oxidation fails to prevent adverse cardiac remodeling but renders itself capable of PDE5 activation.
  • 2014/05 - The Stanley L. Blumenthal CV Retreat Poster Award Cysteine oxidation in PKG-1α plays a critical role in cardiac stress remodeling beyond its kinase activity
  • 2012 - AHA Mid-Atlantic MAA 2012 Postdoctoral Fellowship Grant Cysteine redox regulation in PKG-1alpha against cardiac maladaptive response after pressure overload
  • 2011 - 上原記念生命科学財団 リサーチフェローシップ 圧負荷心肥大と心不全におけるPKG分子機序の解明
  • 2010 - 第23回日本心臓財団・バイエル薬品 海外留学助成 左室拡張不全における内皮型NO合成酵素機能の役割とその分子機序の解明
Association Membership(s) (7):
AMERICAN HEART ASSOCIATION ,  JAPANESE HEART FAILURE SOCIETY ,  THE JAPANESE SOCIETY OF HYPERTENSION ,  THE JAPANESE CIRCULATION SOCIETY ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  JAPAN ASSOCIATION FOR MEDICAL INFORMATICS ,  The Society of Cardiovascular Endocrinology and Metabolism
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