Nakagawa Masahiro

Affiliation and department：

Research field (1)： Tumor biology

Research theme for competitive and other funds (7)：

2022 - 2026 Investigation of development mechanism and preemptive medicine for IDH-mutant glioma based on genomic analysis of normal brain tissues
2022 - 2025 マルチオミクス単一細胞解析を用いた白血病進展機構の解明
2019 - 2024 comprehensive studies on the molecular basis of early development and clonal evolution in cancer using advanced genomics.
2017 - 2020 Analysis of residual disease using newly developed single cell RNA sequencing.
2008 - 2009 Functional analysis of AML1-target genes in hematological malignancy.

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Papers (91)：

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, et al. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms. Blood. 2023. 141. 5. 534-549
Akitada Yogo, Toshihiko Masui, Shigeo Takaishi, Kenji Masuo, Ru Chen, Yosuke Kasai, Kazuyuki Nagai, Takayuki Anazawa, Sadanori Watanabe, Satoko Sakamoto, et al. Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling. Cancer science. 2022
昆彩奈, 中川正宏, 片岡圭亮, 垣内伸之, 牧島秀樹, 越智陽太郎, 中山学, 古関明彦, 南谷泰仁, 小川誠司. 骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明(Elucidating the mechanism of clonal evolution of DDX41 mutated cells in myeloid malignancies). 日本癌学会総会記事. 2022. 81回. E-1066
中川正宏, 稲垣良作, 南谷泰仁, 佐伯龍之介, 越智陽太郎, 竹田淳恵, 趙蘭英, 威星星, 依田成玄, 昆彩奈, et al. 単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing). 日本癌学会総会記事. 2022. 81回. IS8-6
森拓人, 越智陽太郎, 昆彩奈, 吉里哲一, 古関明彦, 依田成玄, 中川正宏, 竹田淳恵, 永田安伸, 吉田健一, et al. 骨髄異形成症候群におけるSRSF2変異とSTAG2変異と協調的関係(Cooperative effects of SRSF2 and STAG2 mutations on development of myelodysplastic syndrome and its related disorders). 日本癌学会総会記事. 2022. 81回. IS11-6

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MISC (51)：

June Takeda, Kenichi Yoshida, Masahiro M. Nakagawa, Yasuhito Nannya, Akinori Yoda, Ryunosuke Saiki, Yotaro Ochi, Lanying Zhao, Rurika Okuda, Xingxing Qi, et al. Amplified EPOR/JAK2 genes definea unique subtype of acute erythroid leukemia. CANCER RESEARCH. 2022. 82. 12
June Takeda, Kenichi Yoshida, Masahiro Marshall Nakagawa, Yasuhito Nannya, Akinori Yoda, Daisuke Morishita, Ryunosuke Saiki, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, et al. EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia. BLOOD. 2021. 138
Ayana Kon, Masahiro Nakagawa, Ryosaku Inagaki, Keisuke Kataoka, Yotaro Ochi, Hideki Makishima, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa. The functional role of compound DDX41 germline and somatic R525H mutations in the development of myeloid neoplasms. CANCER SCIENCE. 2021. 112. 454-454
Masahiro Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, et al. Early Clonal evolution of myeloid malignancies. CANCER SCIENCE. 2021. 112. 969-969
June Takeda, Kenichi Yoshida, Akinori Yoda, Yasuhito Nannya, Masahiro Nakagawa, Yotaro Ochi, Ayana Kon, Tetsuichi Yoshizato, Yusuke Shiozawa, Yuichi Shiraishi, et al. JAK STAT Pathway is a Promising Therapeutic target in Acute Erythroid Leukemia. CANCER SCIENCE. 2021. 112. 453-453

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