Nakanishi Mio

Affiliation and department：
Job title： Lecturer
Homepage URL (1)： https://www.nakanishilab.com

Research field (6)： Medical biochemistry , Developmental biology , Molecular biology , Hematology and oncology , Biomedical engineering , Cell biology

Research keywords (9)： somatic stem cell , pluripotent stem cell , hematopoietic stem cell , regeneration , tissue maturation , aging , cellular plasticity , single cell analysis , bioinformatics

Research theme for competitive and other funds (7)：

2022 - 2028 前駆細胞の脱分化による組織再生メカニズム解明とその制御法の創出
2024 - 2026 造血オルガノイドをもちいた免疫ヒト化モデルの創出
2023 - 2026 フィロスタシス研究を創成支援する総括
2023 - 2026 幹細胞フィロスタシスとその破綻による老化の統合的理解
2021 - 2024 多層的なクロマチン構造破綻による造血幹細胞老化メカニズムの解明

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Papers (21)：

Yukiteru Nakayama, Katsuhito Fujiu, Tsukasa Oshima, Jun Matsuda, Junichi Sugita, Takumi James Matsubara, Yuxiang Liu, Kohsaku Goto, Kunihiro Kani, Ryoko Uchida, et al. Heart failure promotes multimorbidity through innate immune memory. Science immunology. 2024. 9. 95. eade3814
Yuriko Yoneda, Hisaya Kato, Yoshiro Maezawa, Koutaro Yokote, Mio Nakanishi. Real-time imaging of human endothelial-to-hematopoietic transition in vitro using pluripotent stem cell derived hemogenic endothelium. Biophysics and Physicobiology. 2024
Luca Orlando, Yannick D Benoit, Jennifer C Reid, Mio Nakanishi, Allison L Boyd, Juan L García-Rodriguez, Borko Tanasijevic, Meaghan S Doyle, Artee Luchman, Ian J Restall, et al. Chemical genomics reveals targetable programs of human cancers rooted in pluripotency. Cell chemical biology. 2023
Kinga Vojnits, Mio Nakanishi, Deanna Porras, Yeonjoon Kim, Zhuohang Feng, Diana Golubeva, Mick Bhatia. Developing CRISPR/Cas9-Mediated Fluorescent Reporter Human Pluripotent Stem-Cell Lines for High-Content Screening. Molecules (Basel, Switzerland). 2022. 27. 8
Luca Orlando, Borko Tanasijevic, Mio Nakanishi, Jennifer C. Reid, Juan L. García-Rodríguez, Kapil Dev Chauhan, Deanna P. Porras, Lili Aslostovar, Justin D. Lu, Zoya Shapovalova, et al. Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions. Cell Reports. 2021. 34. 10. 108818-108818

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MISC (2)：

Weida Li, Claudia Cavelti-Weder, Yinying Zhang, Kendell Clement, Scott Donovan, Gabriel Gonzalez, Jiang Zhu, Marianne Stemann, Ke Xu, Tatsu Hashimoto, et al. Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells (vol 32, pg 1223, 2014). NATURE BIOTECHNOLOGY. 2015. 33. 8. 882-882
Yasuhiro Seki, Akira Kurisaki, Kanako Watanabe-Susaki, Yoshiro Nakajima, Mio Nakanishi, Yoshikazu Arai, Kunio Shiota, Hiromu Sugino, Makoto Asashima. TIF1 beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner (vol 107, pg 10926, 2010). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010. 107. 30. 13556-13556

Patents (2)：

Books (2)：

実験医学 Vol.37 No.16
羊土社 2019
Biology and Engineering of Stem Cell Niches
Elsevier 2017

Lectures and oral presentations (22)：

Mechanisms of Aging through Multicellular Dynamics Alterations in Hematopoietic Cells
(2024)
Elucidation of Unknown Hematopoietic Stem Cell Initiation Mechanisms through the in Vitro Construction of the Entire Fetal Hematopoietic Organ
(57th Annual Meeting of the Japanese Society of Developmental Biologists (at Kyoto) 2024)
Molecular Mechanisms Underlying Development, Regeneration, and Aging of Hematopoietic Stem Cells
(the 5th Symposium of Division of Synthetic Biology Research, Research Institute for Science and Technology, Tokyo University of Science 2024)
Induction of Maturation into Functional Hematopoietic Stem and Progenitor Cells through the Control of the Hematopoietic Development Environment and Intrinsic Programs.
(The 46th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2022 at Kobe) 2023)
In Vitro Reconstitution of Human Hematopoietic Stem and Progenitor Cells Development
(the 56th JSDB annual meeting (in Sendai) 2023)

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Education (1)：

The University of Tokyo Graduate School of Arts and Sciences

Professional career (1)：

Ph.D. (University of Tokyo)

Work history (5)：

2024/10 - 現在 Japan Science and Technology Agency PRESTO Researcher
2022/04 - 現在 Japan Science and Technology Agency FOREST Researcher
2020/01 - 現在 Chiba University Graduate School of Medicine Lecturer
2013/01 - 2019/12 McMaster University Stem Cell and Cancer Research Institute Postdoc
2010/03 - 2012/12 Harvard Univeristy Department of Stem Cell and Regenerative Biology Postdoc

Committee career (3)：

2022/11 - 現在 Japanese Society for Regenerative Medicine Representative
2022/04 - 現在 Representative, Japan Society for Cell Biology
2023/11 - Japanese Biochemical Society Representative

Awards (13)：

2024/07 - Takeda Science Foundation Visionary Research Grants (Start)
2023/11 - Astellas Foundation for Research on Metabolic Disorders Research Grant (2023)
2023/10 - Naito Memorial Foundation Naito Memorial Science Encouragement Prize & Research Grant
2022/02 - ノバルティス科学振興財団第35回研究奨励金
2021/12 - 東京生化学研究会 2021年度助成金A

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Association Membership(s) (10)：

International Society for Experimental Hematology , International Society for Stem Cell Research , 日本エピジェネティクス研究会 , 細胞生物学会 , 発生生物学会 , 日本血液学会 , 再生医療学会 , 炎症・再生医学会 , 生化学会 , 分子生物学会

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