Nakanishi Mio

Affiliation and department：
Job title： Lecturer

Research field (4)： Medical biochemistry , Developmental biology , Cell biology , Molecular biology

Research keywords (9)： pluripotent stem cell , hematopoietic stem cell , regeneration , tissue maturation , cellular plasticity , single cell analysis , bioinformatics , epigenetics , reprogramming

Research theme for competitive and other funds (6)：

2022 - 2028 前駆細胞の脱分化による組織再生メカニズム解明とその制御法の創出
2023 - 2026 フィロスタシス研究を創成支援する総括
2023 - 2026 幹細胞フィロスタシスとその破綻による老化の統合的理解
2021 - 2024 多層的なクロマチン構造破綻による造血幹細胞老化メカニズムの解明
2021 - 2023 シンギュラリティ細胞の脱分化による組織維持・再生機構の解明

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Papers (20)：

Yuriko Yoneda, Hisaya Kato, Yoshiro Maezawa, Koutaro Yokote, Mio Nakanishi. Real-time imaging of human endothelial-to-hematopoietic transition in vitro using pluripotent stem cell derived hemogenic endothelium. Biophysics and Physicobiology. 2024
Luca Orlando, Yannick D Benoit, Jennifer C Reid, Mio Nakanishi, Allison L Boyd, Juan L García-Rodriguez, Borko Tanasijevic, Meaghan S Doyle, Artee Luchman, Ian J Restall, et al. Chemical genomics reveals targetable programs of human cancers rooted in pluripotency. Cell chemical biology. 2023
Kinga Vojnits, Mio Nakanishi, Deanna Porras, Yeonjoon Kim, Zhuohang Feng, Diana Golubeva, Mick Bhatia. Developing CRISPR/Cas9-Mediated Fluorescent Reporter Human Pluripotent Stem-Cell Lines for High-Content Screening. Molecules (Basel, Switzerland). 2022. 27. 8
Luca Orlando, Borko Tanasijevic, Mio Nakanishi, Jennifer C. Reid, Juan L. García-Rodríguez, Kapil Dev Chauhan, Deanna P. Porras, Lili Aslostovar, Justin D. Lu, Zoya Shapovalova, et al. Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions. Cell Reports. 2021. 34. 10. 108818-108818
Lili Aslostovar, Allison L. Boyd, Yannick D. Benoit, Justin Di Lu, Juan Luis Garcia Rodriguez, Mio Nakanishi, Deanna P. Porras, Jennifer C. Reid, Ryan R. Mitchell, Brian Leber, et al. Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients. Cell Reports Medicine. 2021. 2. 2. 100202-100202

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MISC (2)：

Weida Li, Claudia Cavelti-Weder, Yinying Zhang, Kendell Clement, Scott Donovan, Gabriel Gonzalez, Jiang Zhu, Marianne Stemann, Ke Xu, Tatsu Hashimoto, et al. Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells (vol 32, pg 1223, 2014). NATURE BIOTECHNOLOGY. 2015. 33. 8. 882-882
Yasuhiro Seki, Akira Kurisaki, Kanako Watanabe-Susaki, Yoshiro Nakajima, Mio Nakanishi, Yoshikazu Arai, Kunio Shiota, Hiromu Sugino, Makoto Asashima. TIF1 beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner (vol 107, pg 10926, 2010). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010. 107. 30. 13556-13556

Books (2)：

実験医学 Vol.37 No.16
羊土社 2019
Biology and Engineering of Stem Cell Niches
Elsevier 2017

Lectures and oral presentations (16)：

Tissue regeneration and aging through cellular identity change
(75th Annual Meeting of the Japan Society for Cell Biology 2023)
Controlling biological time: challenges towards manipulation of cell maturation
(45th Annual Meeting of the Molecular Biology Society of Japan 2022)
Plasticity of lineage-restricted progenitors: potential key mechanism underlying homeostasis, regeneration, and ageing of the somatic stem cells
(The 55th Annual Meeting of the Japanese Society of Developmental Biology 2022)
成熟化の壁を越えて成体細胞・組織誘導のための発生時間制御ストラテジー創出
(第21回日本再生医療学会総会シンポジウム39「多能性幹細胞由来細胞・組織の成熟化に挑む」 2022)
Homeostasis of stem cell populations maintained by rare de-differentiating subsets
(The 59th Annual Meeting of the BSJ (online); Symposium 26: Approaches to diverse biological phenomena produced by singularity cells 2021)

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Professional career (1)：

Ph.D. (University of Tokyo)

Committee career (3)：

2022/11 - 現在 Japanese Society for Regenerative Medicine Representative
2022/04 - 現在 Representative, Japan Society for Cell Biology
2023/11 - Japanese Biochemical Society Representative

Awards (12)：

2023/11 - Astellas Foundation for Research on Metabolic Disorders Research Grant (2023)
2023/10 - Naito Memorial Foundation Naito Memorial Science Encouragement Prize & Research Grant
2022/02 - ノバルティス科学振興財団第35回研究奨励金
2021/12 - 東京生化学研究会 2021年度助成金A
2021/11 - 科学技術振興機構創発的研究支援事業・2021年度採択(創発研究者)

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Association Membership(s) (10)：

International Society for Experimental Hematology , International Society for Stem Cell Research , 日本エピジェネティクス研究会 , 細胞生物学会 , 発生生物学会 , 日本血液学会 , 再生医療学会 , 炎症・再生医学会 , 生化学会 , 分子生物学会

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