Rchr

J-GLOBAL ID：201601020801566442 Update date: Sep. 19, 2024

Sasaki Yutaka

ササキユタカ | Sasaki Yutaka

Homepage URL (1)： http://www2.kuh.kumamoto-u.ac.jp/gastro/

Research field (1)： Gastroenterology

Research theme for competitive and other funds (28)：

2021 - 2024 栄養環境がもたらすエピゲノム制御変化の解明に基づく肝発癌増殖進展の制御
2018 - 2021 Investigation on prediction for medical treatment response to advanced hepatocellular carcinoma
2018 - 2021 Analysis of metabolic reprogramming induced by cellular environment and its application to control hepato-carcinogenesis
2017 - 2020 Regulation of invasion and metastasis of colon cancer via Wnt-Cdh1 axis
2014 - 2017 molecular biological analysis of Sessile serrated adenoma/polyp in the proximal colon

2014 - 2017 The role of Cdh1 in colorectal cancer invasion and metastasis

2013 - 2017 Analysis of microenvironment-mediated treatment resistance of hepatocellular carcinoma in terms of integrated proteomics

2014 - 2015 Identification of hepatic maturation mechanisms of human iPS cells by using chemical screening

2012 - 2015 Basic study of the cell cycle related molecules affiliated with liver regeneration and clinical application

2011 - 2013 The role of cell cycle regulator Cdh1 in carcinogenesis and development of gastrointestinal cancer.

2009 - 2012 Analysis of mechanisms underlying treatment-resistance ofhepatocelluar carcinoma in the point view of post-translationalmodification evaluated by proteomics

2009 - 2011 The basic analysis of cell cycle association molecules by controlling the function aiming at application to liver regeneration treatment.

2007 - 2008 The basic analysis of cell cycle association molecules by controlling the function aiming at application to liver regeneration treatment

2006 - 2008 Analysis of molecular mechanisms underlying apoptosis resistance of hepatocellular carcinoma using proteomics

2005 - 2006 Mechanism of Apoptosis Induction by Bacterial Proteases and Its Implication for Bacterial Pathogenesis.

2004 - 2006 消化管アミロイドーシスの進展抑制を目指した免疫療法の開発

2002 - 2004 Analysis of survival signaling and its application for a new therapeutic strategy of cancers in gastro-intestinal tract and liver.

2002 - 2003 新規接着因子ninjurinの強制発現を用いたsenescence分子機構の解明

2001 - 2003 肝細胞癌に対する腫瘍免疫学的制御の分子機構解析

2000 - 2001 Therapeutic strategy for hepatocellular carcinoma by dendritic cell-based tumor vaccination

1999 - 2000 Application of Ninjurin, a novel adhesion molecule, to diagnosis and therapeutics of primary hepatocellular carcinoma

1999 - 2000 Therapetic strategy for chronic hepatitis C by inducing apoptosis of hepatocyte infected with hepatitis C virus

1998 - 2000 Analysis of the molecular mechanism of hepatocarcinogenesis in patients with chronic viral diseases and its application for genetic diagnosis of hepatocellular carcinoma.

1996 - 1997 Analysis of the mechanism of liver damage and carcinogenesis in patients with chronic hepatitis C virus infection.

1995 - 1996 Basic study for gene therapy of human liver cancer in terms of regulating signal trnasduction pathway

1994 - 1995 Biomolecular analysis of liver carcinogenesis in hepatitis C virus infection.

1994 - 1995 Investigation for induction of apoptosis-related genes in hepatitis C virus-infected hepatocytes.

1987 - 1988 Analysis of inhibitory mechanism by ethanol on liver regeneration.

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Papers (326)：

Hiroki Yanagisawa, Hitoshi Maeda, Isamu Noguchi, Motohiko Tanaka, Naoki Wada, Taisei Nagasaki, Kazuki Kobayashi, Gai Kanazawa, Kazuaki Taguchi, Victor Tuan Giam Chuang, et al. Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation. Redox Biology. 2024. 76. 103314-103314
Shusuke Kumazaki, Hayato Hikita, Yuki Tahata, Ji Hyun Sung, Kenji Fukumoto, Yuta Myojin, Sadatsugu Sakane, Kazuhiro Murai, Yoichi Sasaki, Kumiko Shirai, et al. Serum growth differentiation factor 15 is a novel biomarker with high predictive capability for liver cancer occurrence in patients with <scp>MASLD</scp> regardless of liver fibrosis. Alimentary Pharmacology & Therapeutics. 2024. 60. 3. 327-339
Katsuhiko Sato, Hayato Hikita, Minoru Shigekawa, Kazumasa Soma, Ryohei Yamauchi, Jihyun Sung, Seiya Kato, Yoichi Sasaki, Shinnosuke Kudo, Kenji Fukumoto, et al. The serum tenascin C level is a marker of metabolic disorder-related inflammation affecting pancreatic cancer prognosis. Scientific Reports. 2024. 14. 1
Yuki Minayoshi, Hitoshi Maeda, Keisuke Hamasaki, Taisei Nagasaki, Mei Takano, Ryo Fukuda, Yuki Mizuta, Motohiko Tanaka, Yutaka Sasaki, Masaki Otagiri, et al. Mouse Type-I Interferon-Mannosylated Albumin Fusion Protein for the Treatment of Chronic Hepatitis. Pharmaceuticals. 2024. 17. 2. 260-260
Yoko Yoshimaru, Katsuya Nagaoka, Kentaro Tanaka, Satoshi Narahara, Hiroki Inada, Sotaro Kurano, Takayuki Tokunaga, Estuko Iio, Takehisa Watanabe, Hiroko Setoyama, et al. A randomized phase I / II study of vascular endothelial growth factor receptor peptide vaccines for patients with hepatocellular carcinoma. Hepatology Research. 2023

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MISC (430)：

東哲生, 古田陽輝, 直江秀昭, 田村吉高, 池田理, 嶋田圭太, 日比泰造, 佐々木裕, 田中靖人. 貫通静脈を伴う難治性食道静脈瘤に対して経回結腸静脈的塞栓術(TIO)が奏功した1例-Successful treatment of trans-ileocolic vein obliteration for endoscopic treatment refractory esophageal varices accompanied with perforating vein : A case report. 日本門脈圧亢進症学会雑誌 = Japanese journal of portal hypertension / 日本門脈圧亢進症学会編. 2022. 28. 1. 42-47
Satoshi Narahara, Takehisa Watanabe, Katsuya Nagaoka, Nahoko Fujimoto, Kentaro Tanaka, Takayuki Tokunaga, Takeshi Kawasaki, Yoko Yoshimaru, Masakuni Tateyama, Hideaki Naoe, et al. A NOVEL SERUM BIOMARKER, CLUSTERIN, AND RELATED PREDICTIVE INDEX SCORING COULD BE AN EARLY PREDICTOR OF RESPONSE TO SORAFENIB IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA. HEPATOLOGY. 2020. 72. 687A-688A
立山雅邦, 田中基彦, 田中健太郎, 楢原啓史, 徳永堯之, 川崎剛, 吉丸洋子, 長岡克弥, 渡邊丈久, 坂井良成, et al. 当科並びに関連施設におけるIFN free治療後SVR例の肝癌発生、再発の検討. 肝臓. 2019. 60. Suppl.3. A844-A844
徳永尭之, 田中基彦, 田中健太郎, 楢原哲史, 吉丸洋子, 川崎剛, 長岡克弥, 渡邊丈久, 立山雅邦, 佐々木裕. 傾向スコア分析を用いた進行肝細胞癌に対するソラフェニブ治療とレンバチニブ治療の後治療を見据えた治療成績の検討. 肝臓. 2019. 60. Suppl.3. A879-A879
楢原哲史, 立山雅邦, 田中健太郎, 徳永尭之, 川崎剛, 宮本英明, 吉丸洋子, 長岡克弥, 渡邊丈久, 田中基彦, et al. 青年期発症の肝芽腫の1例. 肝臓. 2019. 60. Suppl.3. A929-A929

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Books (32)：

肝臓専門医テキスト
南江堂 2013
「今日の消化器疾患治療指針第3版」 HIV感染症と肝障害
医学書院 2010
「消化器研修ノート」薬物性肝障害
診断と治療社 2009
「臨床栄養療法スタッフマニュアル」逆流性食道炎
医学書院、 2009
「臨床栄養療法スタッフマニュアル」食道アカラジア
医学書院 2009

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Lectures and oral presentations (184)：

ワークショップ移植後における肝疾患の再発と対策、演題名:生体肝移植後症例に対する抗ウイルス療法の現状と問題点
(第39回日本肝臓学会西部会 2011)
シンポジウム:肝硬変患者の栄養マネージメント、治療、演題名アルブミンの構造的・機能的変化から見た分岐鎖アミノ酸治療の意義
(JDDW2011(第15回日本肝臓学会大会・第53回日本消化器病学会大会・第9回日本消化器外科学会大会・第42回日本消化吸収学会総会合同) 2011)
テーマ:慢性肝疾患治療のブレークスルーを目指して演題名:-脾摘 vs PSE- C型肝硬変に対する治療IFN治療-PSE先行、脾摘先行の安全性、有効性の比較検討-
(第18回日本門脈圧亢進症学会総会 2011)
ワークショップ:非B非C肝癌の実態と特徴、演題名:当科における非B非C肝癌の臨床的特徴
(第47回日本肝癌研究会 2011)
ワークショップ代謝・酸化ストレスの場としての肝臓、演題名:慢性肝疾患におけるアルブミンの構造的・機能的変化の検討-特に抗酸化機能について
(第47回日本肝臓学会総会 2011)

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Works (7)：

胃内への胆汁酸逆流の発生頻度と胃粘膜傷害背景因子との関連性についての検討
2006 - 2007
細菌性プロテアーゼによるアポトーシスの誘導と病原性発現機序に関する研究
2005 - 2007
消化管アミロイドーシスの進展抑制を目指した免疫療法の開発
2004 - 2007
血中GPC3抗原の臨床的有用性に関する初期評価
2003 - 2006
消化器癌治療への応用をめざした生存シグナル活性化機構の解明
2002 - 2005

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Education (1)：

- 1979 Osaka University Faculty of Medicine Medical School

Professional career (1)：

医学博士 (大阪大学)

Work history (7)：

2022/04 - 現在 Osaka Central Hospital Department of Gastroenterology Special Consultant
2019/04 - 現在 Kumamoto University Professor Emeritus
2020/04 - 2022/03 Nagasaki International University The Faculty of Health Management Professor
2019/04 - 2020/03 Kaizuka CIty Hospital President
2003/04 - 2019/03 Faculty of Life Sciences, Kumamoto University Department of Gastroenterolgy and Hepatology Professor and Chair man

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Committee career (11)：

2021/04 - 2025/03 独立行政法人医薬品医療機器総合機構専門委員
2021/09 - 2024/09 The Japan Society of Portal Hypertension Auditor
2020/04 - 2024/03 国立研究開発法人日本医療研究開発機構 AMED 産学連携医療イノベーション創出推進プログラムACT-M/MS 課題評価委員
2015/09 - 2021/09 The Japan Society of Portal Hypertension Director
2015/04 - 2021/03 The Japan Society of Gastroenterology Director

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Awards (4)：

2000 - 財団法人ウイルス肝炎研究財団研究奨励賞
1999 - 第28回かなえ医薬振興財団助成
1997 - DMB研究会研究助成
1994 - DMB研究会研究助成

Association Membership(s) (5)：

日本消化管学会 , 日本内科学会 , 日本消化器病学会 , 日本肝臓学会 , 日本消化器内視鏡学会

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