Kizuka Yasuhiko

キヅカヤスヒコ | Kizuka Yasuhiko

Affiliation and department：
Homepage URL (1)： https://www1.gifu-u.ac.jp/~kizuka_2/

Research field (2)： Functional biochemistry , Medical biochemistry

Research keywords (14)： HNK-1 , FUT8 , GnT-V , GnT-III , ケミカルバイオロジー , 糖アナログ , アルツハイマー病 , bisecting GlcNAc , HDAC , 糖鎖生物学 , O-GlcNAc , GnT-IX , 糖転移酵素 , エピジェネティクス

Research theme for competitive and other funds (13)：

2022 - 2026 An extedned research of cell membrane domains based on the probes of membrane molecules
2020 - 2023 Mechanisms of cancer and Alzheimer's disease involving glycan branching
2017 - 2022 神経疾患糖鎖の発現機構・作用原理の解明とケミカルツールの開発
2018 - 2021 Modulation of cancer cells by core fucose-specific antibody
2017 - 2020 Mechanisms of expression and action of neurodegeneration-promoting glycan bisecting GlcNAc

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Papers (92)：

Seita Tomida, Masamichi Nagae, Yasuhiko Kizuka. Distinctive domains and activity regulation of core fucosylation enzyme FUT8. Biochimica et Biophysica Acta - General Subjects. 2024. 1868. 4
Seita Tomida, Masamichi Nagae, Yasuhiko Kizuka. Distinctive domains and activity regulation of core fucosylation enzyme FUT8. Biochimica et biophysica acta. General subjects. 2024. 1868. 4. 130561-130561
Reina F Osuka, Masamichi Nagae, Akito Ohuchi, Shiho Ohno, Yoshiki Yamaguchi, Yasuhiko Kizuka. The cancer-associated glycosyltransferase GnT-V (MGAT5) recognizes the N-glycan core via residues outside its catalytic pocket. FEBS letters. 2023
Satoshi Ninagawa, Masaki Matsuo, Deng Ying, Shinya Aso, Kazutoshi Matsushita, Akane Fueki, Shunsuke Saito, Koshi Imami, Yasuhiko Kizuka, Tetsushi Sakuma, et al. UGGT1/2-mediated reglucosylation ofN-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins. 2023
Noriko Kanto, Yuki Ohkawa, Masato Kitano, Kento Maeda, Masafumi Shiida, Tatsuya Ono, Fumi Ota, Yasuhiko Kizuka, Kei Kunimasa, Kazumi Nishino, et al. A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2. The Journal of biological chemistry. 2023. 299. 12. 105365-105365

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MISC (98)：

長田菜緒子, 長江雅倫, 長江雅倫, 中の三弥子, MISHRA Sushil K., DOERKSEN Robert J., 木塚康彦, 木塚康彦. Recognition of self N-glycan by lectin domain of GnT-IV glycosyltransferase. 日本糖質学会年会要旨集. 2023. 42nd
橋本雄太, 川出遥加, 森井爽, 中の三弥子, 長江雅倫, 長江雅倫, 木塚康彦, 木塚康彦. Analysis of the regulatory mechanisms of intracellular activity of GnT-III K346T mutant. 日本糖質学会年会要旨集. 2023. 42nd
富田晟太, 長江雅倫, 木塚康彦, 木塚康彦. Analysis of regulation mechanisms of activity of fucosyltransferase FUT8. 日本糖質学会年会要旨集. 2023. 42nd
長田菜緒子, 長江雅倫, 木塚康彦. 糖転移酵素GnT-IVa,-IVbの糖タンパク質基質に対する選択性の研究. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3T02a-06
富田晟太, 長江雅倫, 木塚康彦. Stem領域によるフコース転移酵素FUT8の多量体形成の制御. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3T02a-08

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Education (3)：

2006 - 2009 Kyoto University Graduate School of Pharmaceutical Sciences
2004 - 2006 Kyoto University Graduate School of Pharmaceutical Sciences
2000 - 2004 Kyoto University Faculty of Pharmaceutical Sciences

Professional career (1)：

博士(薬学) (京都大学)

Work history (9)：

2022/04 - 現在 Gifu University Institute for Glycosylation-core Research (iGCORE) Professor
2022 - 現在お茶の水女子大学ヒューマンライフサイエンス研究所客員准教授
2020/04 - 現在 Tokai National Higher Education and Research System Institute for Glyco-core Research (iGCORE) Director's Advisor
2018/04 - 現在 Osaka International Cancer Institute Visiting Researcher
2021/01 - 2022/03 岐阜大学糖鎖生命コア研究所糖鎖分子科学研究センターセンター長・准教授

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Committee career (1)：

2019/07 - 2020/06 独立行政法人日本学術振興会特別研究員審査委員

Awards (5)：

2017 - 日本生化学会奨励賞
2015 - 日本糖質学会奨励賞
2015 - 理化学研究所研究奨励賞
2012 - 日本糖質学会ポスター賞
2011 - 日本生化学会鈴木紘一メモリアル賞

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