Konishi Akimitsu

コニシアキミツ | Konishi Akimitsu

Affiliation and department：
Job title： Lecturer
Homepage URL (1)： http://tenure.showa.gunma-u.ac.jp

Research field (1)： Medical biochemistry

Research keywords (11)： aging , amino acid metabolism , 細胞老化 , テロメア , 細胞周期チェックポイント , ゲノム安定性 , DNA損傷応答 , telomere , cell cycle checkpoint , genome integrity , DNA damage response

Research theme for competitive and other funds (17)：

2021 - 2024 Elucidation of a novel cellular senescence mechanism modulated by branched-chain amino acid metabolism.
2017 - 2020 Understanding mechanism of genome instability in hereditary breast cancer induced by telomere dysfunction
2017 - 2020 エピゲノム疾患の解明と治療戦略の開発
2016 - 2017 AIDシステムを利用したヒト細胞でのシェルテリン複合体によるテロメア機能の解析
2014 - 2017 テニュアトラック普及・定着事業(個人選抜型)

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Papers (24)：

Xian Zhao, Keisuke Kiyozuka, Akimitsu Konishi, Reika Kawabata-Iwakawa, Yoji Andrew Minamishima, Hideru Obinata. Actin-binding protein Filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1. The Journal of biological chemistry. 2023. 104851-104851
Keisuke Kiyozuka, Xian Zhao, Akimitsu Konishi, Yoji Andrew Minamishima, Hideru Obinata. Apolipoprotein M supports S1P production and conservation and mediates prolonged Akt activation via S1PR1 and S1PR3. Journal of biochemistry. 2023
Yuji Tanaka, Hideru Obinata, Akimitsu Konishi, Noriyuki Yamagiwa, Makoto Tsuneoka. Production of ROS by Gallic Acid Activates KDM2A to Reduce rRNA Transcription. Cells. 2020. 9. 10. 2266-2266
Tanaka Y, Konishi A, Obinata H, Tsuneoka M. Metformin activates KDM2A to reduce rRNA transcription and cell proliferation by dual regulation of AMPK activity and intracellular succinate level. Scientific Reports. 2019. 9. 1. 18694
Meruna Nagata, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hazuki Endo, Masatsune Tsujioka, Shinya Honda, Yuya Nishida, Akimitsu Konishi, Shigeomi Shimizu. Dram1 regulates DNA damage-induced alternative autophagy. Cell stress. 2018. 2. 3. 55-65

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MISC (18)：

大日方英, 小西昭充. 分岐鎖アミノ酸代謝の変調と老化・加齢性疾患. 基礎老化研究. 2024. 48. 1. 3-8
Akimitsu KONISHI. Mitochondria pathway of apoptosis. 2022. 183. 5. 317-321
土田愛子, 入江和樹, 荒牧佑磨, 南嶋洋司, 小西昭充. Proteomic analysis in senescent cells induced by telomere shortening. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
小西昭充, 荒牧佑磨, 大日方英, 南嶋洋司. 分岐鎖アミノ酸代謝の変調と細胞・個体老化. がんと代謝研究会プログラム&抄録集. 2022. 8th
小西昭充, 荒牧佑磨, 大日方英, 本田真也, 和泉孝志, 清水重臣, 南嶋洋司. Modulation of Cellular Senescence by Branched-Chain Amino Acid Metabolism. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th

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Lectures and oral presentations (63)：

Actin-binding protein Filamin B regulates endothelial sphingosine 1-phosphate receptor 1 functions by keeping the receptor on cell-surface
(2023)
テロメア短縮系を用いた効率的な複製老化系の樹立および分岐鎖アミノ酸代謝の細胞老化における役割の解析
(第96回日本生化学会大会 2023)
Involvement of Branched-Chain Amino Acid Metabolism in Cellular Senescence and Aging
(2023)
代謝物解析から迫る細胞・個体老化〜分岐鎖アミノ酸代謝の変調を中心に〜
(第46回日本基礎老化学会大会 2023)
細胞老化過程における分岐鎖アミノ酸代謝の変調
(第71回質量分析総合討論会 2023)

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Education (2)：

1999 - 2003 Nagoya City University Graduate School of Medical Sciences
1988 - 1994 Nagoya City University

Professional career (1)：

MD, Ph.D. (Nagoya City University)

Work history (9)：

2017/04 - 現在 Gunma University Graduate School of Medicine
2013/03 - 2017/03 Gunma University Graduate School of Medicine
2011/04 - 2013/03 東京医科歯科大学・難治疾患研究所病態細胞生物学講師
2008/02 - 2011/03 東京医科歯科大学・難治疾患研究所 MTTプログラム特任助教
2005/10 - 2008/03 Human Frontier Science Program 長期フェロー(兼務)

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Committee career (2)：

2022/10 - 現在 Frontiers in Cell and Developmental Biology Editorial Board of Cell Death and Survival
2018/01 - 現在日本生化学会日本生化学会英文誌 The Journal of Biochemistry (JB) Advisory Board(Molecular Biology 部門)

Awards (2)：

2005 - Human Frontier Science Program Long-term Fellowship
2005 - 上原記念生命科学財団リサーチフェローシップ

Association Membership(s) (5)：

日本生化学会 , 米国生化学分子生物学会 , 日本癌学会 , 日本分子生物学会 , American Society for Biochemistry and Molecular Biology

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