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J-GLOBAL ID：201602200754374434   Reference number：16A0046364

TC-2559, an α4β2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages

α4β2ニコチン性アセチルコリン受容体作動薬TC-2559は培養ネズミマクロファージにおいてSTAT3阻害を介してCCL3及びIL-1β発現を抑制する

Author (6)： KIGUCHI Norikazu (Wakayama Medical Univ., Wakayama, JPN) ,  KIGUCHI Norikazu (Wake Forest Univ. School of Medicine, NC, USA) ,  SAIKA Fumihiro (Wakayama Medical Univ., Wakayama, JPN) ,  KOBAYASHI Yuka (Wakayama Medical Univ., Wakayama, JPN) ,  KO Mei-Chuan (Wake Forest Univ. School of Medicine, NC, USA) ,  KISHIOKA Shiroh (Wakayama Medical Univ., Wakayama, JPN)
Material： Journal of Pharmacological Sciences (Web)  (J Pharmacol Sci (Web))
Volume： 128  Issue： 2  Page： 83-86 (WEB ONLY)  Publication year： Jun. 2015 
JST Material Number： U0667A  ISSN： 1347-8613  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： CCL3 ,...

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JST classification (2)： Basic neurology  (GN01020W) ,  Basic research of parasympathetics  (GW05032S)

Substance index (1)： TC-2559

Reference (15)：

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• Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest. 2007;117:289-296.
• Gotti C, Zoli M, Clementi F. Brain nicotinic acetylcholine receptors: native subtypes and their relevance. Trends Pharmacol Sci. 2006;27:482-491.

Terms in the title (11)： ニコチン性アセチルコリン受容体 ,  作動薬 ,  Tc ,  培養 ,  ネズミ ,  マクロファージ ,  STAT3 ,  阻害 ,  CCL3 ,  IL-1β ,  発現