Art

J-GLOBAL ID：201602202458921767   Reference number：16A0268899

Development of a Transnasal Delivery System for Recombinant Human Growth Hormone (rhGH): Effects of the Concentration and Molecular Weight of Poly-L-arginine on the Nasal Absorption of rhGH in Rats

組換えヒト成長ホルモン(rhGH)に対する経鼻送達システムの開発:ラットにおけるrhGHの鼻吸収に対するポリL-アルギニンの濃度と分子量の影響

Author (13)： KAWASHIMA Ryo (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  UCHIDA Masaki (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  YAMAKI Tsutomu (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  OHTAKE Kazuo (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  HATANAKA Tomomi (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  HATANAKA Tomomi (Tokai Univ. School of Medicine) ,  UCHIDA Hiroyuki (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  UEDA Hideo (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  KOBAYASHI Jun (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  MORIMOTO Yasunori (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  MORIMOTO Yasunori (Res. Inst. of TTS Technol., Josai Univ.) ,  NATSUME Hideshi (Fac. of Pharmaceutical Sciences, Josai Univ.) ,  NATSUME Hideshi (Res. Inst. of TTS Technol., Josai Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 39  Issue： 3  Page： 329-335 (J-STAGE)  Publication year： 2016 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： *Human Growth Hormone ,...

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JST classification (1)： Physicochemical pharmacy in general  (GV01010J)

Reference (24)：

• 1) Parmentier J, Hofhaus G, Thomas S, Cuesta LC, Gropp F, Schröder R, Hartmann K, Fricker G. Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether-lipids and omeprazole. J. Pharm. Sci., 103, 3985-3993 (2014).
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• 3) Rawat A, Yang T, Hussain A, Ahsan F. Complexation of a poly-L-arginine with low molecular weight heparin enhances pulmonary absorption of the drug. Pharm. Res., 25, 936-948 (2008).
• 4) Hartmann K, Ittner J, Müller-Rossberg E, Schönau E, Stephan R, Ullrich KP, Hoppe B, Ramseger R, Brämswig J. Growth hormone treatment adherence in prepubertal and pubertal children with different growth disorders. Horm. Res. Paediatr., 80, 1-5 (2013).
• 5) Cutfield WS, Derraik JGB, Gunn AJ, Reid K, Delany T, Robinson E, Hofman PL. Non-compliance with growth hormone treatment in children is common and impairs linear growth. PLoS ONE, 6, e16223 (2011).

Terms in the title (8)： 組換えヒト成長ホルモン ,  鼻 ,  送達 ,  開発 ,  ラット ,  鼻吸収 ,  L-アルギニン ,  分子量