Art

J-GLOBAL ID：201602202534436717   Reference number：16A0268972

Chemical Hybridization of Vizantin and Lipid A to Generate a Novel LPS Antagonist

新規LPS拮抗薬を発生させるビザンチンと脂質Aの化学交雑化

Author (14)： YAMAMOTO Hirofumi (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  ODA Masataka (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  ODA Masataka (Div. of Microbiology and Infectious Diseases, Niigata Univ. Graduate School of Medical and Dental Sciences) ,  KANNO Marina (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  TAMASHIRO Shota (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  TAMURA Ikuko (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  YONEDA Toshihiko (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  YAMASAKI Naoto (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  DOMON Hisanori (Div. of Microbiology and Infectious Diseases, Niigata Univ. Graduate School of Medical and Dental Sciences) ,  NAKANO Mayo (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  TAKAHASHI Hironobu (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  TERAO Yutaka (Div. of Microbiology and Infectious Diseases, Niigata Univ. Graduate School of Medical and Dental Sciences) ,  KASAI Yusuke (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.) ,  IMAGAWA Hiroshi (Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ.)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 64  Issue： 3  Page： 246-257 (J-STAGE)  Publication year： 2016 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *glycoprotein ,...

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JST classification (1)： Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (9)： 6-O-[2-Deoxy-3-O-(3-undecyltetradecanoyl)-2-(3-undecyltetradecanoylamino)-β-D-glucopyranosyl]-2-deoxy-3-O-[(R)-3-hydroxytetradecanoyl]-2-[(R)-3-hydroxytetradecanoylamino]-4-O-phosphono-α-D-glucopyranose 1-phosphoric acid ,  6-O-[2-Deoxy-3-O-(3-tridecylhexadecanoyl)-2-(3-tridecylhexadecanoylamino)-β-D-glucopyranosyl]-2-deoxy-3-O-[(R)-3-hydroxytetradecanoyl]-2-[(R)-3-hydroxytetradecanoylamino]-4-O-phosphono-α-D-glucopyranose 1-phosphoric acid ,  6-O-[2-Deoxy-3-O-(3-nonyldodecanoyl)-2-[(R)-3-(dodecanoyloxy)tetradecanoylamino]-β-D-glucopyranosyl]-2-deoxy-3-O-[(R)-3-hydroxytetradecanoyl]-2-[(R)-3-hydroxytetradecanoylamino]-4-O-phosphono-α-D-glucopyranose 1-phosphoric acid ,  6-O-[2-Deoxy-3-O-(3-nonyldodecanoylamino)-2-(3-nonyldodecanoylamino)-β-D-glucopyranosyl]-2-deoxy-3-O-[(R)-3-hydroxytetradecanoyl]-2-[(R)-3-hydroxytetradecanoylamino]-4-O-phosphono-α-D-glucopyranose 1-phosphoric acid ,  6-O-[2-Deoxy-3-O-(3-heptyldecanoyl)-2-(3-heptyldecanoylamino)-β-D-glucopyranosyl]-2-deoxy-3-O-[(R)-3-hydroxytetradecanoyl]-2-[(R)-3-hydroxytetradecanoylamino]-4-O-phosphono-α-D-glucopyranose 1-phosphoric acid ,  6-O-[2-Deoxy-3-O-(3-pentyloctanoyl)-2-(3-pentyloctanoylamino)-β-D-glucopyranosyl]-2-deoxy-3-O-[(R)-3-hydroxytetradecanoyl]-2-[(R)-3-hydroxytetradecanoylamino]-4-O-phosphono-α-D-glucopyranose 1-phosphoric acid ,  6-O-[2-Deoxy-3-O-[(R)-3-(tetradecanoyloxy)tetradecanoyl]-2-(3-nonyldodecanoylamino)-β-D-glucopyranosyl]-2-deoxy-3-O-[(R)-3-hydroxytetradecanoyl]-2-[(R)-3-hydroxytetradecanoylamino]-4-O-phosphono-α-D-glucopyranose 1-phosphoric acid ,  TBU-101 ,  Lipid A (E.coli)

Reference (34)：

• 1) Tidswell M., Tillis W., LaRosa S. P., Lynn M., Wittek A. E., Kao R., Wheeler J., Gogate J., Opal S. M., Eritoran Sepsis Study Group, Crit. Care Med., 38, 72-83 (2010).
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• 4) Parrillo J. E., N. Engl. J. Med., 328, 1471-1477 (1993).
• 5) Kulp A., Kuehn M. J., Annu. Rev. Microbiol., 64, 163-184 (2010).

Terms in the title (6)： LPS ,  拮抗薬 ,  ビザンチン ,  脂質 ,  化学 ,  交雑