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J-GLOBAL ID：201602206298931472   Reference number：16A0268895

An Approach to Improve Intestinal Absorption of Poorly Absorbed Water-Insoluble Components via Niemann-Pick C1-Like 1

Niemann-Pick C1様1を介する吸収不良性非水溶性成分の腸吸収を改善するためのアプローチ

Author (9)： TAKEKAWA Yuto (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  SATO Yuki (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  YAMAKI Yoshiaki (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  IMAI Mei (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  NOTO Kazuma (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  SUMI Masato (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  TAKEKUMA Yoh (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  ISEKI Ken (Fac. of Pharmaceutical Sciences, Hokkaido Univ.) ,  SUGAWARA Mitsuru (Fac. of Pharmaceutical Sciences, Hokkaido Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 39  Issue： 3  Page： 301-307 (J-STAGE)  Publication year： 2016 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Membrane Proteins ,...
Semi thesaurus term： *Niemann-Pick C1 like 1

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JST classification (1)： Basic medicine on digestive system  (GH01020E)

Substance index (4)： BODIPY ,  Ezetimibe ,  Cholesterol ,  Coenzyme Q10

Reference (25)：

• 1) van Heek M, Farley C, Compton DS, Hoos L, Davis HR. Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function. Br. J. Pharmacol., 134, 409-417 (2001).
• 2) Altmann SW, Davis HR Jr, Zhu LJ, Yao X, Hoos LM, Tetzloff G, Iyer SP, Maguire M, Golovko A, Zeng M, Wang L, Murgolo N, Graziano MP. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science, 303, 1201-1204 (2004).
• 3) Yu L. The structure of Niemann-Pick C1-Like 1 protein. Curr. Opin. Lipidol., 19, 263-269 (2008).
• 4) Betters JL, Yu L. NPC1L1 and cholesterol transport. FEBS Lett., 584, 2740-2747 (2010).
• 5) Narushima K, Takada T, Yamanashi Y, Suzuki H. Niemann-Pick C1-Like 1 mediates α-tocopherol transport. Mol. Pharmacol., 74, 42-49 (2008).

Terms in the title (4)： C1 ,  吸収不良 ,  水溶性成分 ,  腸