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J-GLOBAL ID：201602210168962500   Reference number：16A1395634

Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice

CRISPR/Cas9によるバイシストロニックノックインins1-cre driverマウスの作製

Author (19)： Hasegawa Yoshikazu (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Hoshino Yoshikazu (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Hoshino Yoshikazu (Hoshino Laboratory Animals, Inc., 1405 Kouda, Bando, Ibaraki 306-0606, Japan) ,  Ibrahim Abdelaziz E. (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ibrahim Abdelaziz E. (Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt) ,  Kato Kanako (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Daitoku Yoko (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Tanimoto Yoko (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ikeda Yoshihisa (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Ikeda Yoshihisa (Charles River Laboratories Japan, Inc., 955 Kamibayashi, Ishioka, Ibaraki 315-0138, Japan) ,  Oishi Hisashi (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Takahashi Satoru (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Takahashi Satoru (International Institute for Integrative Sleep Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Yoshiki Atsushi (Experimental Animal Division, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan) ,  Yagami Ken-ichi (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Iseki Hiroyoshi (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Iseki Hiroyoshi (International Institute for Integrative Sleep Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Mizuno Seiya (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan) ,  Sugiyama Fumihiro (Laborarory Animal Resource Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan)
Material： Experimental Animals  (実験動物ニュース)
Volume： 65  Issue： 3  Page： 319-327(J-STAGE)  Publication year： 2016 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： *genome editing ,...

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Author keywords (5)： bicistronic ,  cre-loxP ,  CRISPR/Cas9 ,  pancreatic β cells ,  mouse

JST classification (1)： Gene manipulation  (EC02050B)

Reference (15)：

• 1. Chan H.Y., V S., Xing X., Kraus P., Yap S.P., Ng P., Lim S.L., and Lufkin T. 2011. Comparison of IRES and F2A-based locus-specific multicistronic expression in stable mouse lines. PLoS ONE 6: e28885.
• 2. Cong L., Ran F.A., Cox D., Lin S., Barretto R., Habib N., Hsu P.D., Wu X., Jiang W., Marraffini L.A., and Zhang F. 2013. Multiplex genome engineering using CRISPR/Cas systems. Science 339: 819-823.
• 3. Dor Y., Brown J., Martinez O.I., and Melton D.A. 2004. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46.
• 4. Hasegawa Y., Daitoku Y., Mizuno S., Tanimoto Y., Mizuno-Iijima S., Matsuo M., Kajiwara N., Ema M., Oishi H., Miwa Y., Mekada K., Yoshiki A., Takahashi S., Sugiyama F., and Yagami K. 2014. Generation and characterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP recombination. Exp. Anim. 63: 183-191.
• 5. Hasegawa Y., Daitoku Y., Sekiguchi K., Tanimoto Y., Mizuno-Iijima S., Mizuno S., Kajiwara N., Ema M., Miwa Y., Mekada K., Yoshiki A., Takahashi S., Sugiyama F., and Yagami K. 2013. Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination. Exp. Anim. 62: 295-304.

Terms in the title (5)： CRISPR ,  Cas9 ,  Cre ,  マウス ,  作製