Art

J-GLOBAL ID：201602210389086675   Reference number：16A0030432

Development of Novel PET Probes for Central 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors

中枢2-アミノ-3-(3-ヒドロキシ-5-メチル-4-イソオキサゾリル)プロピオン酸受容体のための新規なPETプローブ開発

Author (14)： OI Norihito (Eisai Co., Ltd., Ibaraki, JPN) ,  OI Norihito (National Inst. of Radiological Sci., Chiba, JPN) ,  TOKUNAGA Masaki (National Inst. of Radiological Sci., Chiba, JPN) ,  SUZUKI Michiyuki (Eisai Co., Ltd., Ibaraki, JPN) ,  SUZUKI Michiyuki (National Inst. of Radiological Sci., Chiba, JPN) ,  NAGAI Yuji (National Inst. of Radiological Sci., Chiba, JPN) ,  NAKATANI Yosuke (Eisai Co., Ltd., Ibaraki, JPN) ,  NAKATANI Yosuke (National Inst. of Radiological Sci., Chiba, JPN) ,  YAMAMOTO Noboru (Eisai Co., Ltd., Ibaraki, JPN) ,  MAEDA Jun (National Inst. of Radiological Sci., Chiba, JPN) ,  MINAMIMOTO Takafumi (National Inst. of Radiological Sci., Chiba, JPN) ,  ZHANG Ming-Rong (National Inst. of Radiological Sci., Chiba, JPN) ,  SUHARA Tetsuya (National Inst. of Radiological Sci., Chiba, JPN) ,  HIGUCHI Makoto (National Inst. of Radiological Sci., Chiba, JPN)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 58  Issue： 21  Page： 8444-8462  Publication year： Nov. 12, 2015 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： carbon isotope ,  *AMPA receptor ,  *central nervous system drug ,  *radiopharmaceutical ,  radioreceptor assay ,  PET (tomography) ,  *labeled compound ,  drug design ,  in vivo experiment ,  Rattus ,  monkey and ape ,  vascular permeability ,  Blood-Brain Barrier ,  drug absorption ,  Computer Simulation ,  chemical synthesis ,  drug interaction ,  targeting ,  nitrogen heterocyclic compound ,  screening (inspection) ,  carbon 11 ,  blood-brain barrier permeability ,  Molecular Docking Simulation ,  drug synthesis ,  Pyrimidines ,  *PET agent ,  Myomorpha ,  property ,  Cardiovascular System ,  computer application ,  utilization
Semi thesaurus term： *AMPA受容体アンタゴニスト ,  *PET imaging agent ,  drug screening

JST classification (3)： Basic research of radiopharmaceuticals  (GW18010O) ,  Labeled compounds  (CB10050N) ,  Pyrimidines  (CF07103W)

Substance index (2)： Perampanel ,  2-[1-[3-[(¹¹C)Methylamino]phenyl]-5-(2-pyrimidinyl)-2-oxo-1,2-dihydropyridine-3-yl]benzonitrile

Terms in the title (4)： プロピオン酸 ,  受容体 ,  PETプローブ ,  開発