Art

J-GLOBAL ID：201602210806736718   Reference number：16A0057164

Upregulation of energy metabolism-related, p53-target TIGAR and SCO2 in HuH-7 cells with p53 mutation by geranylgeranoic acid treatment

p53突然変異を持つHuH-7細胞へのゲラニルゲラン酸処理によるエネルギー代謝関連,p53標的TIGARとSCO2のアップレギュレーション

Author (2)： IWAO Chieko (Molecular and Cellular Biology, Graduate School of Human Health Sci., Univ. of Nagasaki) ,  SHIDOJI Yoshihiro (Molecular and Cellular Biology, Graduate School of Human Health Sci., Univ. of Nagasaki)
Material： Biomedical Research  (Biomed Res)
Volume： 36  Issue： 6  Page： 371-381 (J-STAGE)  Publication year： 2015 
JST Material Number： Z0236B  ISSN： 0388-6107  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *tumor cell ,...
Semi thesaurus term： TIGAR遺伝子 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=16A0057164&from=J-GLOBAL&jstjournalNo=Z0236B") }}

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Biological function  (EB05020M)

Substance index (1)： Geranylgeranoic acid

Reference (30)：

• 1 Araki H, Shidoji Y, Yamada Y, Moriwaki H and Muto Y (1995) Retinoid agonist activities of synthetic geranyl geranoic acid derivatives. Biochem Biophys Res Commun 209, 66-72.
• 2 Bensaad K, Cheung EC and Vousden KH (2009) Modulation of intracellular ros levels by tigar controls autophagy. EMBO J 28, 3015-3026.
• 3 Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E and Vousden KH (2006) Tigar, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107-120.
• 4 Dai Q, Yin Y, Liu W, Wei L, Zhou Y, Li Z, You Q, Lu N and Guo Q (2013) Two p53-related metabolic regulators, tigar and sco2, contribute to oroxylin a-mediated glucose metabolism in human hepatoma hepg2 cells. Int J Biochem Cell Biol 45, 1468-1478.
• 5 Green DR and Chipuk JE (2006) P53 and metabolism: Inside the tigar. Cell 126, 30-32.

Terms in the title (7)： p53突然変異 ,  Huh-7細胞 ,  ゲラニルゲラン酸 ,  エネルギー代謝 ,  p53 ,  標的 ,  アップレギュレーション