Art

J-GLOBAL ID：201602211227910303   Reference number：16A0252439

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

高脂肪食は腸前駆細胞の幹細胞性と腫瘍発生性を高める

Author (32)： BEYAZ Semir (MIT, Massachusetts, USA) ,  MANA Miyeko D. (MIT, Massachusetts, USA) ,  ROPER Jatin (MIT, Massachusetts, USA) ,  KEDRIN Dmitriy (MIT, Massachusetts, USA) ,  BAUER-ROWE Khristian E. (MIT, Massachusetts, USA) ,  XIFARAS Michael E. (MIT, Massachusetts, USA) ,  AKKAD Adam (MIT, Massachusetts, USA) ,  ARIAS Erika (MIT, Massachusetts, USA) ,  SHINAGARE Shweta (MIT, Massachusetts, USA) ,  ABU-REMAILEH Monther (MIT, Massachusetts, USA) ,  MIHAYLOVA Maria M. (MIT, Massachusetts, USA) ,  DOGUM Rizkullah (MIT, Massachusetts, USA) ,  SABATINI David M. (MIT, Massachusetts, USA) ,  YILMAZ OEmer H. (MIT, Massachusetts, USA) ,  BEYAZ Semir (Harvard Medical School, Massachusetts, USA) ,  GUO Guoji (Harvard Medical School, Massachusetts, USA) ,  ORKIN Stuart H. (Harvard Medical School, Massachusetts, USA) ,  ROPER Jatin (Tufts Medical Center, Massachusetts, USA) ,  KEDRIN Dmitriy (Harvard Medical School, Massachusetts, USA) ,  SELIG Martin (Harvard Medical School, Massachusetts, USA) ,  NIELSEN G. Petur (Harvard Medical School, Massachusetts, USA) ,  FERRONE Cristina R. (Harvard Medical School, Massachusetts, USA) ,  DESHPANDE Vikram (Harvard Medical School, Massachusetts, USA) ,  YILMAZ OEmer H. (Harvard Medical School, Massachusetts, USA) ,  SAADATPOUR Assieh (Harvard T. H. Chan School of Public Health, Massachusetts, USA) ,  PINELLO Luca (Harvard T. H. Chan School of Public Health, Massachusetts, USA) ,  YUAN Guo-Cheng (Harvard T. H. Chan School of Public Health, Massachusetts, USA) ,  HONG Sue-Jean (MIT, Massachusetts, USA) ,  BELL George W. (MIT, Massachusetts, USA) ,  KATZ Yarden (MIT, Massachusetts, USA) ,  LAMMING Dudley W. (Univ. Wisconsin-Madison, Wisconsin, USA) ,  GUPTA Nitin (Univ. Mississippi Medical Center, Missisippi, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 531  Issue： 7592  Page： 53-58  Publication year： Mar. 03, 2016 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： high fat diet ,  cell ,  stem cell ,  *obesity ,  intestine ,  PPAR ,  replication ,  cellular signal transduction ,  tumor suppressor protein ,  experimental disease ,  mouse(animal) ,  *intestinal tumor ,  glycoprotein ,  scleroprotein ,  fatty acid ,  hypolipidemic drug ,  small intestine ,  colon ,  catenin ,  transcription factor ,  *tumorigenesis
Semi thesaurus term： *tumorigenesis ,  APC protein ,  PPAR delta ,  beta Catenin ,  オルファクトメジン4 ,  autonomously replicating ability ,  committed stem cell

JST classification (4)： Carcinogenic mechanisms and factors  (GE02020C) ,  Intestines  (EJ06040N) ,  Tumors(=neoplasms)of digestive system  (GH04000D) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (2)： GW-501516 ,  Palmitic Acid

Terms in the title (5)： 高脂肪食 ,  腸 ,  前駆細胞 ,  幹細胞性 ,  腫瘍発生