Art

J-GLOBAL ID：201602211565764975   Reference number：16A0127448

7-Ketocholesterol-induced lysosomal dysfunction exacerbates vascular smooth muscle cell calcification via oxidative stress

7-ケトコレステロール誘発性リソソーム機能不全は酸化ストレスを介した血管平滑筋細胞の石灰化を悪化させる

Author (4)： SUDO Ryo (Dep. of Tissue Regeneration, Hoshi Univ. School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku ...) ,  SATO Fumiaki (Dep. of Analytical Pathophysiology, Hoshi Univ. School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara ...) ,  AZECHI Takuya (Dep. of Tissue Regeneration, Hoshi Univ. School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku ...) ,  WACHI Hiroshi (Dep. of Tissue Regeneration, Hoshi Univ. School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku ...)
Material： Genes to Cells  (Genes Cells)
Volume： 20  Issue： 12  Page： 982-991  Publication year： Dec. 2015 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *lysosome ,...
Semi thesaurus term： *Vascular Calcification ,...

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JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Cardiovascular system diseases  (GJ03000C)

Substance index (1)： 7-Ketocholesterol

Reference (33)：

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• Brunk, U.T., Jones, C.B. & Sohal, R.S. (1992) A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat. Res. 275, 395-403.
• Butler, D. & Bahr, B.A. (2006) Oxidative stress and lysosomes: CNS-related consequences and implications for lysosomal enhancement strategies and induction of autophagy. Antioxid. Redox Signal. 8, 185-196.
• Byon, C.H., Javed, A., Dai, Q., Kappes, J.C., Clemens, T.L., Darley-Usmar, V.M., Medonald, J.M. & Chen, Y. (2008) Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J. Biol. Chem. 283, 15319-15327.

Terms in the title (7)： 7-ケトコレステロール ,  リソソーム ,  機能不全 ,  酸化ストレス ,  血管平滑筋細胞 ,  石灰化 ,  悪化