Art

J-GLOBAL ID：201602211993980690   Reference number：16A0170556

Development of Anti-fibrosis Drug using HSP47 siRNA~Vitamin A-coupled Lipid Nanoparticle for Stellate Cell-Targeting DDS~

HSP47 siRNAを用いた線維症治療薬の開発~ビタミンA修飾リポソームによる星細胞標的化DDS~

Author (2)： MINOMI KENJIRO (日東電工) ,  NIITSU YOSHIRO (札幌医大 分子標的探索)
Material： Drug Delivery System  (DDS)
Volume： 31  Issue： 1  Page： 62-70  Publication year： Jan. 25, 2016 
JST Material Number： X0225A  ISSN： 0913-5006  CODEN： DDSYEI  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *Liver Cirrhosis ,...
Semi thesaurus term： *ビタミンA修飾リポソーム

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JST classification (2)： Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G) ,  Clinical biopharmacy  (GY01022L)

Reference (11)：

• 1)Sato Y. et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol. 2008 Apr; 26(4): 431-42.
• 2)Ying W. et al. Development of Novel Lipidnanoparticle siRNA Delivery System Targeting Collagen Chaperone Protein HSP47 for Clinical Treatment of Liver Fibrosis. 65th Annual Meeting of the American Association for the Study of Liver Diseases(AASLD 2014) Boston, Massachusetts, November 7-11, 2014. Abstract 452.
• 3)Wake K. Perisinusoidal stellate cells(fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. Int Rev Cytol. 1980; 66: 303-53.
• 4)Watari N. et al. Morphological studies on a vitamin A-storing cell and its complex with macrophage observed in mouse pancreatic tissues following excess vitamin A administration. Okajimas Folia Anat Jpn. 1982 Mar; 58(4-6): 837-58.
• 5)Ikejiri N. The vitamin A-storing cells in the human and rat pancreas. Kurume Med J. 1990; 37(2): 67-81.

Terms in the title (9)： HSP47 ,  siRNA ,  線維症 ,  治療薬 ,  開発 ,  ビタミンA ,  修飾 ,  リポソーム ,  標的化