Art

J-GLOBAL ID：201602213605345006   Reference number：16A1363924

Improving water solubility of nateglinide by complexation of β-cyclodextrin

β-シクロデキストリンの錯体化によるナテグリニドの水溶性の改善

Author (9)： Ikeda Hirohito (Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Fukushige Yuri (Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Matsubara Tomonori (Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Inenaga Masaaki (Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Kawahara Mitsunobu (Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Yukawa Miho (Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan) ,  Fujisawa Masao (Faculty of Biology-Oriented Science and Technology, Kinki University, Wakayama, Japan) ,  Yukawa Eiji (Daiichi University of Pharmacy, Fukuoka, Japan) ,  Aki Hatsumi (Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan)
Material： Journal of Thermal Analysis and Calorimetry  (J Therm Anal Calorimetry)
Volume： 123  Issue： 3  Page： 1847-1850  Publication year： Mar. 2016 
JST Material Number： H0095C  ISSN： 1388-6150  CODEN： JTHEA  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *complex formation ,  *hypoglycemic drug ,  *cyclodextrin ,  water solubility ,  *solubility(ratio) ,  *clathrate compound ,  calorimetry ,  modeling ,  molecular structure ,  Gibbs free energy ,  steric conformation ,  energy ,  molecular orbital calculation
Semi thesaurus term： isothermal titration calorimetry ,  molecular modeling ,  solvation energy

Author keywords (5)： Nateglinide ,  β-Cyclodextrin ,  Inclusion complex ,  Isothermal titration calorimetry ,  Molecular orbital calculation

JST classification (2)： Molecular compounds  (CE02000C) ,  Phase equilibrium,phase diagram of mulicomponent systems(org. subs.)  (CB03016J)

Substance index (2)： β-Cyclodextrin ,  Nateglinide

Terms in the title (4)： β-シクロデキストリン ,  錯体化 ,  ナテグリニド ,  水溶性