Art

J-GLOBAL ID：201602214100095437   Reference number：16A1200942

Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety

コレステロール部分を有するポリプレックスナノミセルを用いた膵臓腫瘍治療のためのmRNAの全身デリバリー

Author (12)： Uchida Satoshi (Laboratory of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kinoh Hiroaki (Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan) ,  Ishii Takehiko (Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan) ,  Matsui Akitsugu (Laboratory of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Tockary Theofilus Agrios (Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan) ,  Takeda Kaori Machitani (Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan) ,  Uchida Hirokuni (Laboratory of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Osada Kensuke (Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan) ,  Itaka Keiji (Laboratory of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kataoka Kazunori (Laboratory of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan) ,  Kataoka Kazunori (Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan) ,  Kataoka Kazunori (Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan)
Material： Biomaterials
Volume： 82  Page： 221-228  Publication year： Mar. 2016 
JST Material Number： C0964B  ISSN： 0142-9612  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *mRNA ,  *drug delivery system ,  *micelle ,  block copolymer ,  polyethylene oxide ,  polyelectrolyte ,  polyion complex ,  *pancreatic tumor ,  experimental disease ,  therapy ,  time course ,  *nanomicelle ,  polycation(macromolecule) ,  polyplex ,  cancer bearing mouse ,  sterol ,  alicyclic alcohol
Semi thesaurus term： anti-angiogenesis therapy ,  *systemic delivery

Author keywords (6)： mRNA delivery ,  Polyplex nanomicelle ,  Cholesterol ,  Enzymatic degradation ,  Pancreatic cancer ,  Anti-angiogenic therapy

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G)

Substance index (1)： Cholesterol

Terms in the title (5)： コレステロール ,  膵臓腫瘍 ,  治療 ,  mRNA ,  全身デリバリー