Art

J-GLOBAL ID：201602214158818280   Reference number：16A1390980

Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

創薬促進のためのCryo-EM解像度の限界の打破

Author (11)： Merk Alan (Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA) ,  Bartesaghi Alberto (Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA) ,  Banerjee Soojay (Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA) ,  Falconieri Veronica (Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA) ,  Rao Prashant (Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA) ,  Davis Mindy I. (National Center for Advancing Translational Sciences, 9800 Medical Center Drive, Rockville, MD 20850, USA) ,  Pragani Rajan (National Center for Advancing Translational Sciences, 9800 Medical Center Drive, Rockville, MD 20850, USA) ,  Boxer Matthew B. (National Center for Advancing Translational Sciences, 9800 Medical Center Drive, Rockville, MD 20850, USA) ,  Earl Lesley A. (Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA) ,  Milne Jacqueline L.S. (Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA) ,  Subramaniam Sriram (Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 165  Issue： 7  Page： 1698-1707  Publication year： Jun. 16, 2016 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *electron microscope ,  freeze sectioning ,  electron microscopy ,  resolving power ,  *isocitrate dehydrogenase ,  space structure ,  variation ,  lactate dehydrogenase ,  Glutamate Dehydrogenase ,  structural change ,  *cryoelectron microscope
Semi thesaurus term： *cryo-electron microscope

JST classification (1)： Molecular structure  (EB03020Y)

Terms in the title (5)： 創薬 ,  促進 ,  CRYO-EM ,  解像度 ,  限界