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J-GLOBAL ID：201602214218403587   Reference number：16A1289412

Extrastriatal spreading of microglial activation in Parkinson’s disease: a positron emission tomography study

パーキンソン病におけるミクログリア活性化の線条体外広がり:陽電子放射断層撮影研究

Author (9)： Terada Tatsuhiro (Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Yokokura Masamichi (Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Yoshikawa Etsuji (Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan) ,  Futatsubashi Masami (Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Japan) ,  Kono Satoshi (First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Konishi Takashi (First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Miyajima Hiroaki (First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Hashizume Takanori (Osaka Ohtani University, Tondabayashi, Japan) ,  Ouchi Yasuomi (Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan)
Material： Annals of Nuclear Medicine  (Ann Nucl Med)
Volume： 30  Issue： 8  Page： 579-587  Publication year： Oct. 2016 
JST Material Number： X0838A  ISSN： 0914-7187  CODEN： ANMEEX  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *Parkinson's disease ,...
Semi thesaurus term： *immunological reaction ,...

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Author keywords (4)： Parkinson’s disease (PD) ,  Microglia ,  [11C]DPA713 ,  Positron emission tomography (PET)

JST classification (1)： Neurologic diagnosis  (GN02000H)

Substance index (1)： ¹¹C-DPA-713

Reference (29)：

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• Ouchi Y, Yoshikawa E, Sekine Y, Futatsubashi M, Kanno T, Ogusu T, et al. Microglial activation and dopamine terminal loss in early Parkinson’s disease. Ann Neurol. 2005;57:168-75.
• Banati RB, Daniel SE, Blunt SB. Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson’s disease. Mov Disord. 1998;13:221-7.
• McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson’s and Alzheimer’s disease brains. Neurology. 1988;38:1285-91.
• Ouchi Y, Yagi S, Yokokura M, Sakamoto M. Neuroinflammation in the living brain of Parkinson’s disease. Parkinsonism Relat Disord. 2009;15(Suppl 3):S200-4.

Terms in the title (6)： パーキンソン病 ,  ミクログリア活性化 ,  線条体 ,  広がり ,  陽電子放射断層撮影 ,  研究