Art

J-GLOBAL ID：201602214350018430   Reference number：16A0127604

Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor

μオピオイド受容体の効果および機能的選択性を決定する立体配座平衡の同定

Author (15)： OKUDE Junya (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  UEDA Takumi ,  KOFUKU Yutaka (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  SATO Motohiko (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  NOBUYAMA Naoyuki (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  KONDO Keita (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  SHIRAISHI Yutaro (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  MIZUMURA Takuya (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  ONISHI Kento (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  NATSUME Mei (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  MAEDA Masahiro (Shionogi Co., Ltd., Discovery Res. Laboratories, Osaka 561-0825 (Japan)) ,  TSUJISHITA Hideki (Shionogi Co., Ltd., Discovery Res. Laboratories, Osaka 561-0825 (Japan)) ,  KURANAGA Takefumi (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  INOUE Masayuki (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)) ,  SHIMADA Ichio (Graduate School of Pharmaceutical Sciences, The Univ. of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan). ...)
Material： Angewandte Chemie. International Edition  (Angewandte Chemie. International Edition in English)
Volume： 54  Issue： 52  Page： 15771-15776  Publication year： Dec. 21, 2015 
JST Material Number： H0127B  ISSN： 1433-7851  CODEN： ACIEAY  Document type： Article
Article type： 短報  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *membrane receptor ,  mu receptor ,  conformational equilibrium ,  lipid bilayer membrane ,  Membrane Proteins ,  *NMR ,  Proteins ,  amino acid residue ,  *G protein-coupled receptor ,  Arrestin ,  Signal Transduction ,  methionine residue ,  ligand binding ,  Isotope Labeling
Semi thesaurus term： cellular signal transduction ,  *mu opioid receptor ,  Lipid Bilayers ,  *conformational equilibrium

JST classification (1)： Biological function  (EB03040U)

Terms in the title (4)： μオピオイド受容体 ,  選択性 ,  立体配座平衡 ,  同定