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J-GLOBAL ID：201602214803372672   Reference number：16A0145291

Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds

25-ヒドロキシ-25(または26)-アダマンチル-17-[20(22),23-ジイニル]-21-ノルビタミンD化合物の合成と生物学的活性とX線結晶構造解析
Author (10)：
WATARAI Yusuke

About WATARAI Yusuke

(Rikkyo Univ., Tokyo, JPN)

About Rikkyo Univ., Tokyo, JPN

, 
ISHIZAWA Michiyasu

About ISHIZAWA Michiyasu

(Nihon Univ. School of Medicine, Tokyo, JPN)

About Nihon Univ. School of Medicine, Tokyo, JPN

, 
IKURA Teikichi

About IKURA Teikichi

(Tokyo Medical and Dental Univ., Tokyo, JPN)

About Tokyo Medical and Dental Univ., Tokyo, JPN

, 
ZACCONI Flavia C. M.

About ZACCONI Flavia C. M.

(Universidad de Santiago de Compostela, Santiago de Compostela, ESP)

About Universidad de Santiago de Compostela, Santiago de Compostela, ESP

, 
UNO Shigeyuki

About UNO Shigeyuki

(Nihon Univ. School of Medicine, Tokyo, JPN)

About Nihon Univ. School of Medicine, Tokyo, JPN

, 
ITO Nobutoshi

About ITO Nobutoshi

(Tokyo Medical and Dental Univ., Tokyo, JPN)

About Tokyo Medical and Dental Univ., Tokyo, JPN

, 
MOURINO Antonio

About MOURINO Antonio

(Universidad de Santiago de Compostela, Santiago de Compostela, ESP)

About Universidad de Santiago de Compostela, Santiago de Compostela, ESP

, 
TOKIWA Hiroaki

About TOKIWA Hiroaki

(Rikkyo Univ., Tokyo, JPN)

About Rikkyo Univ., Tokyo, JPN

, 
MAKISHIMA Makoto

About MAKISHIMA Makoto

(Nihon Univ. School of Medicine, Tokyo, JPN)

About Nihon Univ. School of Medicine, Tokyo, JPN

, 
YAMADA Sachiko

About YAMADA Sachiko

(Nihon Univ. School of Medicine, Tokyo, JPN)

About Nihon Univ. School of Medicine, Tokyo, JPN


Material：
Journal of Medicinal Chemistry  (J Med Chem)

About Journal of Medicinal Chemistry


Volume： 58  Issue： 24  Page： 9510-9521  Publication year： Dec. 24, 2015 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
vitamin D receptor

About vitamin D receptor

, 
cycloalkane

About cycloalkane

, 
bridged compound

About bridged compound

, 
drug

About drug

, 
cell physiology

About cell physiology

, 
uptake

About uptake

, 
stability

About stability

, 
X-ray structural analysis

About X-ray structural analysis

, 
crystal structure

About crystal structure

, 
chemical synthesis

About chemical synthesis

, 
*fat-soluble vitamin

About fat-soluble vitamin

, 
osteoblast

About osteoblast

, 
transcription(genetics)

About transcription(genetics)

, 
drug for treatment of osteoporosis

About drug for treatment of osteoporosis

, 
mineral metabolism

About mineral metabolism


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
adamantane derivative

About adamantane derivative

, 
partial agonist

About partial agonist

, 
cell uptake

About cell uptake

, 
chemical stability

About chemical stability

, 
drug synthesis

About drug synthesis

, 
*Vitamin D derivatives

About Vitamin D derivatives

, 
calcium metabolism

About calcium metabolism


JST classification (2)：
JST classification
Category name(code) classified by JST.
Basic research of other drugs acting on metabolism 
(GW13060I)

About Basic research of other drugs acting on metabolism

,  Basic medicine on musculoskeletal system 
(GG01020B)

About Basic medicine on musculoskeletal system

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
(7E,25S)-2-Methylene-25-(1-adamantyl)-9,10-seco-19,21,26,27-tetranorcholesta-5,7-diene-20(22),23-diyne-1α,3β,25-triol

About (7E,25S)-2-Methylene-25-(1-adamantyl)-9,10-seco-19,21,26,27-tetranorcholesta-5,7-diene-20(22),23-diyne-1α,3β,25-triol

Terms in the title (2)：
Terms in the title
Keywords automatically extracted from the title.
生物学的活性

About 生物学的活性

, 
X線結晶構造解析

About X線結晶構造解析


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