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J-GLOBAL ID：201602215581009783   Reference number：16A0005247

Cu-ATSM PETイメージングと診断一体型治療(Theranostics)への応用

Author (4)： YOSHII YUKIE (放医研 分子イメージング研究セ) ,  FURUKAWA TAKAKO (放医研 分子イメージング研究セ) ,  FUJIBAYASHI YASUHISA (放医研 分子イメージング研究セ) ,  SAGA TSUNEO (放医研 分子イメージング研究セ)
Material： 臨床核医学  (Nuclear Medicine in Clinic)
Volume： 48  Issue： 6  Page： 84-87  Publication year： Nov. 20, 2015 
JST Material Number： X0177A  ISSN： 0912-5817  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human(primates) ,...
Semi thesaurus term： Cu-ATSM PET ,...

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JST classification (3)： Radiotherapy for tumors  (GE03034K) ,  Clinical application of radiopharmaceuticals  (GW18020Z) ,  Clinical radiology in general  (GC04013Y)

Substance index (1)： ⁶⁴Cu-ATSM

Reference (20)：

• Fujibayashi Y, Cutler CS, Anderson CJ, et al. Comparative studies of Cu-64-ATSM and C-11-acetate in an acute myocardial infarction model: ex vivo imaging of hypoxia in rats. Nucl Med Biol 1999; 26: 117-21.
• Fujibayashi Y, Taniuchi H, Yonekura Y, et al. Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med 1997; 38: 1155-60.
• Obata A, Yoshimi E, Waki A, et al. Retention mechanism of hypoxia selective nuclear imaging/radiotherapeutic agent cu-diacetyl-bis (N⁴-methylthiosemicarbazone) (Cu-ATSM) in tumor cells. Ann Nucl Med 2001; 15: 499-504.
• Dehdashti F, Grigsby PW, Lewis JS, et al. Assessing tumor hypoxia in cervical cancer by PET with ⁶⁰Cu-labeled diacetyl-bis(N⁴⁰- methylthiosemicarbazone). J Nucl Med 2008; 49: 201-5.
• Dehdashti F, Grigsby PW, Mintun MA, et al. Assessing tumor hypoxia in cervical cancer by positron emission tomography with ⁶⁰Cu-ATSM: relationship to therapeutic response-a preliminary report. Int J Radiat Oncol Biol Phys 2003; 55: 1233-8.

Terms in the title (8)： Cu ,  ATSM ,  PET ,  イメージング ,  診断 ,  体型 ,  治療 ,  応用