Art

J-GLOBAL ID：201602216221575438   Reference number：16A0647296

The progress of biologics in the rheumatic disease

リウマチ性疾患における生物学的製剤の進歩

Author (1)： KAWAHITO YUTAKA (京都府医大 大学院医学研究科 免疫内科学 膠原病・リウマチ・アレルギー科)
Material： 臨床リウマチ  (Clinical Rheumatology and Related Research)
Volume： 28  Issue： 2  Page： 97-105  Publication year： Jun. 30, 2016 
JST Material Number： L0625A  ISSN： 0914-8760  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： rheumatism ,...
Semi thesaurus term： Rituximab

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JST classification (2)： Clinical application of immunotherapeutic agents and blood preparations  (GW22020O) ,  Clinical application of anti-inflammatory drugs  (GW15020E)

Reference (39)：

• 1) Genovese MC, Fleischmann R, Kivitz AJ, et al: Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a Phase III Study. Arthritis Rheumatol, 67:1424-1437, 2015.
• 2) Smolen JS, Weinblatt ME, Sheng S, et al: a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy. Ann Rheum Dis, 73:1616-1625, 2014.
• 3) Weinblatt ME, Mease P, Mysler E, et al: The Efficacy and Safety of Subcutaneous Clazakizumab in Patients With Moderate-to-Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results From a Multinational, Phase IIb, Randomized, Double-Blind, Placebo/Active-Controlled, Dose-Ranging Study. Arthritis Rheum, 67:2591-2600, 2015.
• 4) Genovese MC, Durez P, Richards HB, et al: Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Ann Rheum Dis, 72:863-869, 2013.
• 5) Pavelka K, Chon Y, Newmark R, et al: A study to evaluate the safety, tolerability, and efficacy of brodalumab in subjects with rheumatoid arthritis and an inadequate response to methotrexate. J Rheumatol, 42:912-919, 2015.

Terms in the title (2)： リウマチ性疾患 ,  生物学的製剤