Art

J-GLOBAL ID：201602218346696061   Reference number：16A1395625

Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice

成体マウスにおける広範および一時的な遺伝子改変のためのタモキシフェン誘導Cre-driverマウス系統の確立

Author (8)： Ichise Hirotake (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Hori Akiko (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Shiozawa Seiji (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Kondo Saki (Laboratory of Molecular Genetics, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Kanegae Yumi (Laboratory of Molecular Genetics, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Saito Izumu (Laboratory of Molecular Genetics, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Ichise Taeko (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Yoshida Nobuaki (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan)
Material： Experimental Animals  (実験動物ニュース)
Volume： 65  Issue： 3  Page： 231-244(J-STAGE)  Publication year： 2016 
JST Material Number： Z0755A  ISSN： 1341-1357  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *gene manipulation ,...
Semi thesaurus term： Cre/loxP ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=16A1395625&from=J-GLOBAL&jstjournalNo=Z0755A") }}

Author keywords (5)： FLP/FRT ,  mouse ,  SV40 large T antigen ,  tamoxifen-inducible Cre ,  tumorigenesis

JST classification (1)： Gene manipulation  (EC02050B)

Substance index (1)： Tamoxifen

Reference (30)：

• 1. Anastassiadis K., Glaser S., Kranz A., Berhardt K., and Stewart A.F. 2010. A practical summary of site-specific recombination, conditional mutagenesis, and tamoxifen induction of CreERT2. Methods Enzymol. 477: 109-123.
• 2. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A. Jr., Butel J.S., and Bradley A. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
• 3. Feil R., Brocard J., Mascrez B., LeMeur M., Metzger D., and Chambon P. 1996. Ligand-activated site-specific recombination in mice. Proc. Natl. Acad. Sci. USA 93: 10887-10890.
• 4. Friedrich G. and Soriano P. 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5: 1513-1523.
• 5. Hayashi S. and McMahon A.P. 2002. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev. Biol. 244: 305-318.

Terms in the title (7)： 成体 ,  マウス ,  遺伝子改変 ,  タモキシフェン ,  誘導 ,  Cre ,  系統