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J-GLOBAL ID：201602220176219669   Reference number：16A0268905

Rhein 8-O-β-D-Glucopyranoside Elicited the Purgative Action of Daiokanzoto (Da-Huang-Gan-Cao-Tang), Despite Dysbiosis by Ampicillin

レイン8-O-β-D-グルコピラノシドは,アンピシリンによる腸内菌共生バランス失調にもかかわらず,大黄甘草湯(Da-Huang-Gan-Cao-Tang)の下剤作用を誘発した

Author (4)： TAKAYAMA Kento (Fac. of Pharmacy and Pharmaceutical Sciences, Fukuyama Univ.) ,  TABUCHI Norihiko (Fac. of Pharmacy and Pharmaceutical Sciences, Fukuyama Univ.) ,  FUKUNAGA Masahito (Fac. of Pharmacy and Pharmaceutical Sciences, Fukuyama Univ.) ,  OKAMURA Nobuyuki (Fac. of Pharmacy and Pharmaceutical Sciences, Fukuyama Univ.)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 39  Issue： 3  Page： 378-383 (J-STAGE)  Publication year： 2016 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： Bacteroides ,...

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JST classification (1)： Basic research of drugs acting on digestive system  (GW09010Q)

Substance index (3)： 1-O-(3-Carboxy-9,10-dihydro-1-hydroxy-9-oxoanthracen-8-yl)-β-D-glucopyranose ,  Ampicillin ,  Sennoside A

Reference (38)：

• 1) Miyoshi A, Masamune O, Fukutomi H, Mori H, Miwa T, Kojima K, Aono M, Nakajima M. The clinical effect of TSUMURA daiokanzoto extract granules for ethical use (TJ-84) by double blind test against the constipation. Gastroenterology, 18, 299-312 (1994).
• 2) Miyoshi A, Masamune O, Fukutomi H, Mori H, Miwa T, Kojima K, Aono M, Nakajima M. The clinical effect of TSUMURA daiokanzoto extract granules for ethical use (TJ-84) against the constipation based on the new standard. Gastroenterology, 22, 314-328 (1996).
• 3) Matsumoto M, Ishige A, Yazawa Y, Kondo M, Muramatsu K, Watanabe K. Promotion of intestinal peristalsis by Bifidobacterium spp. capable of hydrolyzing sennosides in mice. PLoS ONE, 7, e31700 (2012).
• 4) Hattori M, Namba T, Akao T, Kobashi K. Metabolism of sennosides by human intestinal bacteria. Pharmacology, 36 (Suppl. 1), 172-179 (1988).
• 5) Kobashi K, Nishimura T, Kusaka M, Hattori M, Namba T. Metabolism of sennosides by human intestinal bacteria. Planta Med., 40, 225-236 (1980).

Terms in the title (12)： レイン ,  アンピシリン ,  腸 ,  菌 ,  共生 ,  バランス ,  失調 ,  大黄甘草湯 ,  GaN ,  CaO ,  下剤 ,  誘発