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J-GLOBAL ID：201602221830972635   Reference number：16A1277037

Promoter hypomethylation of RAR-related orphan receptor α 1 is correlated with unfavorable clinicopathological features in patients with colorectal cancer

RAR関連オーファン受容体α1のプロモータ低メチル化は結腸直腸癌の患者における不適な臨床病理学的特徴と関連する

Author (6)： Kano Hisao (Department of Cancer Genetics, Nihon University School of Medicine) ,  Kano Hisao (Department of Digestive Surgery, Nihon University School of Medicine) ,  Takayama Tadatoshi (Department of Digestive Surgery, Nihon University School of Medicine) ,  Midorikawa Yutaka (Department of Digestive Surgery, Nihon University School of Medicine) ,  Nagase Hiroki (Department of Cancer Genetics, Nihon University School of Medicine) ,  Nagase Hiroki (Division of Cancer Genetics, Chiba Cancer Center Research Institute)
Material： BioScience Trends  (BST)
Volume： 10  Issue： 3  Page： 202-209(J-STAGE)  Publication year： 2016 
JST Material Number： L8367A  ISSN： 1881-7815  CODEN： BTIRCZ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Methylation ,...
Semi thesaurus term： *colorectal cancer ,...

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Author keywords (4)： DNA methylation ,  RORA ,  colorectal cancer ,  prognostic factor

JST classification (1)： Tumors(=neoplasms)of digestive system  (GH04000D)

Reference (26)：

• 1. Grady WM, Carethers JM. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology. 2008; 135:1079-1799.
• 2. Shinojima Y, Terui T, Hara H, et al. Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation. J Dermatol Sci. 2010; 59:98-106.
• 3. Watanabe T, Yachi K, Ohta T, Fukushima T, Yoshino A, Katayama Y, Shinojima Y, Terui T, Nagase H. Aberrant hypermethylation of non-promoter zygote arrest 1 (ZAR1)in human brain tumors. Neurol Med Chir. 2010; 50:1062-1069.
• 4. Fujiwara K, Ghosh S, Liang P, Morien E, Soma M, Nagase H. Genome-wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers. Mol Carcinog. 2015; 54:178-188.
• 5. Sugito K, Kawashima H, Uekusa S, et al. Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions. Pediatr Blood Cancer. 2013; 60:383-389.

Terms in the title (6)： オーファン受容体 ,  プロモータ ,  低メチル化 ,  結腸直腸癌 ,  患者 ,  臨床病理学