Art

J-GLOBAL ID：201602222327501096   Reference number：16A0562444

VCPモジュレータを用いた難治眼疾患に対する新規治療法開発

Author (3)： IKEDA HANAKO (京大 医 病院 臨床研究総合セ) ,  KAKIZUKA AKIRA (京大) ,  YOSHIMURA NAGAHISA (京大 医学研究科 眼科)
Material： 臨床薬理の進歩  (Recent Advances in Clinical Pharmacology)
Issue： 37  Page： 8-15  Publication year： Jun. 20, 2016 
JST Material Number： Y0720A  ISSN： 0914-4366  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： *VCP protein ,...

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JST classification (3)： Basic ophthalmology  (GP01020C) ,  Basic research of drugs acting on sensory organs  (GW04060K) ,  Visual sense  (EJ13020B)

Substance index (3)： adenosine triphosphate ,  KUS-187 ,  KUS-121

Reference (7)：

• Iwase A, Suzuki Y, Araie M, Yamamoto T, Abe H, Shirato S, et al. The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study. Ophthalmol 2004; 111: 1641-8.
• Meyer H, Bug M, Bremer S. Emerging functions of the Vcp/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol 2012; 14: 117-23.
• Ye Y. Diverse functions with a common regulator: Ubiquitin takes command of an aaa ATPase. J Struct Biol 2006; 156: 29-40.
• Ikeda HO, Sasaoka N, Koike M, Nakano N, Muraoka Y, Toda Y, et al. Novel vcp modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa. Sci Rep 2014; 4: 5970.
• Manno A, Noguchi M, Fukushi J, Motohashi Y,Kakizuka A. Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia. Genes Cells 2010; 15: 911-22.

Terms in the title (5)： VCP ,  モジュレータ ,  眼疾患 ,  治療法 ,  開発