Art

J-GLOBAL ID：201602222935069323   Reference number：16A1133991

APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers

APOBEC3B遺伝子高発現状態は,日本人乳癌患者の攻撃的表現型と関連する

Author (13)： Tsuboi Miki (Department of Thoracic Visceral Organ Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan) ,  Tsuboi Miki (Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan) ,  Yamane Arito (Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan) ,  Horiguchi Jun (Department of Thoracic Visceral Organ Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan) ,  Yokobori Takehiko (Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan) ,  Kawabata-Iwakawa Reika (Initiative for Advanced Research, Gunma University, Maebashi, Gunma, Japan) ,  Yoshiyama Shinji (Initiative for Advanced Research, Gunma University, Maebashi, Gunma, Japan) ,  Rokudai Susumu (Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan) ,  Odawara Hiroki (Department of Surgery, Toho Hospital, Midorishi, Gunma, Japan) ,  Tokiniwa Hideaki (Department of Thoracic Visceral Organ Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan) ,  Oyama Tetsunari (Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan) ,  Takeyoshi Izumi (Department of Thoracic Visceral Organ Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan) ,  Nishiyama Masahiko (Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan)
Material： Breast Cancer
Volume： 23  Issue： 5  Page： 780-788  Publication year： Sep. 2016 
JST Material Number： L3971A  ISSN： 1340-6868  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *Cytidine Deaminase ,...
Semi thesaurus term： Papillomavirus ,...

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Author keywords (3)： Breast cancer ,  APOBEC3B ,  Nuclear grade

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Biological function  (EB03040U)

Reference (21)：

• Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW. Cancer genome landscapes. Science. 2013;339:1546-58.
• Helleday T, Eshtad S, Nik-Zainal S. Mechanisms underlying mutational signatures in human cancers. Nat Rev Genet. 2014;15:585-98.
• Burns MB, Lackey L, Carpenter MA, Rathore A, Land AM, Leonard B, et al. APOBEC3B is an enzymatic source of mutation in breast cancer. Nature. 2013;494:366-70.
• Burns MB, Temiz NA, Harris RS. Evidence for APOBEC3B mutagenesis in multiple human cancers. Nat Genet. 2013;45:977-83.
• Mori S, Takeuchi T, Ishii Y, Kukimoto I. Identification of APOBEC3B promoter elements responsible for activation by human papillomavirus type 16 E6. Biochem Biophys Res Commun. 2015;460:555-60.

Terms in the title (7)： 遺伝子 ,  発現 ,  日本人 ,  乳 ,  癌患者 ,  攻撃 ,  表現型