Art

J-GLOBAL ID：201602224751854964   Reference number：16A1396182

Immunofluorescence Labeling of a Mutant of Tissue Non-Specific Alkaline Phosphatase Lacking the Glysosylphosphatidylinositol Anchor

グリコシルホスファチジルイノシトールアンカーを欠く組織非特異的なアルカリホスファターゼの変異体の免疫蛍光標識

Author (3)： Matsumura Tomohiro (Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Nippon Medical School) ,  Saito Shiho (Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Nippon Medical School) ,  Orimo Hideo (Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Nippon Medical School)
Material： Journal of Nippon Medical School  (日本医科大学雑誌)
Volume： 83  Issue： 4  Page： 140-141(J-STAGE)  Publication year： 2016 
JST Material Number： F0887A  ISSN： 1345-4676  CODEN： JNMSF5  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *glyceroglycolipid ,...
Semi thesaurus term： *glycosylphosphatidylinositol-anchor ,...

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JST classification (3)： Enzyme in general  (EB09010D) ,  Gene manipulation  (EC02050B) ,  Basic diagnostics  (GC03002P)

Substance index (1)： LipofectAMINE

Reference (3)：

• 1. Millan JL, Whyte MP: Alkaline phosphatase and hypophosphatasia. Calcif Tissue Int 2016; 98: 398-416.
• 2. Komaru K, Ishida Y, Amaya Y, Goseki-Sone M, Orimo H, Oda K: Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension: Retarded secretion and proteasomal degradation. FEBS J 2005; 272: 1704-1717.
• 3. Orimo H, Hayashi Z, Watanabe A, Hirayama T, Hirayama T, Shimada T: Novel missense and frameshift mutations in the tissue-nonspecific alkaline phosphatase gene in a Japanese patient with hypophosphatasia. Hum Mol Genet 1994; 3: 1683-1684.

Terms in the title (6)： グリコシルホスファチジルイノシトールアンカー ,  組織 ,  アルカリホスファターゼ ,  変異体 ,  免疫 ,  蛍光標識