Art

J-GLOBAL ID：201602227666652608   Reference number：16A1395590

Identification of Candidate Target Cyp Genes for microRNAs Whose Expression Is Altered by PCN and TCPOBOP, Representative Ligands of PXR and CAR

PXRおよびCARの代表的リガンド,PCNおよびTCPOBOPにより発現が変化するマイクロRNAに対する候補標的Cyp遺伝子の同定

Author (4)： Moriya Nozomu (Department of Biopharmaceutics, Hyogo University of Health Sciences) ,  Kataoka Hiromi (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Nishikawa Jun-ichi (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Kugawa Fumihiko (Department of Biopharmaceutics, Hyogo University of Health Sciences)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 39  Issue： 8  Page： 1381-1386(J-STAGE)  Publication year： 2016 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： *CAR ,...

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Author keywords (10)： microRNA ,  cytochrome P450 ,  nuclear receptor ,  pregnane X receptor (PXR) ,  constitutive androstane receptor (CAR) ,  microRNA ,  cytochrome P450 ,  nuclear receptor ,  pregnane X receptor (PXR) ,  constitutive androstane receptor (CAR)

JST classification (1)： Gene expression  (EC02040Q)

Substance index (1)： TCPOBOP

Reference (22)：

• 1) Barrett LW, Fletcher S, Wilton SD. Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements. Cell. Mol. Life Sci., 69, 3613-3634 (2012).
• 2) Huang Y, Shen XJ, Zou Q, Wang SP, Tang SM, Zhang GZ. Biological functions of microRNAs: a review. J. Physiol. Biochem., 67, 129-139 (2011).
• 3) Ikemura K, Iwamoto T, Okuda M. MicroRNAs as regulators of drug transporters, drug-metabolizing enzymes, and tight junctions: implication for intestinal barrier function. Pharmacol. Ther., 143, 217-224 (2014).
• 4) Singh D, Kashyap A, Pandey RV, Saini KS. Novel advances in cytochrome P450 research. Drug Discov. Today, 16, 793-799 (2011).
• 5) Pan YZ, Gao W, Yu AM. MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab. Dispos., 37, 2112-2117 (2009).

Terms in the title (9)： PXR ,  リガンド ,  PCN ,  TCPOBOP ,  発現 ,  マイクロRNA ,  標的 ,  CYP遺伝子 ,  同定