Art

J-GLOBAL ID：201602230625582917   Reference number：16A1341645

Angiogenesis in refractory depression: A possible phenotypic target to avoid the blood brain barrier

難治性うつ病における血管新生:血液脳関門を回避するための可能性のある表現型標的

Author (1)： Yamada Maki K. (Isotope Science Center, The University of Tokyo)
Material： Drug Discoveries & Therapeutics  (DD & T)
Volume： 10  Issue： 2  Page： 74-78(J-STAGE)  Publication year： 2016 
JST Material Number： F1177A  ISSN： 1881-7831  CODEN： DDTRBX  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *depression (disease) ,...
Semi thesaurus term： *intractable depression ,...

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Author keywords (5)： BBB ,  VEGF ,  pericyte ,  vasculogenesis ,  SERT

JST classification (3)： Physicochemical pharmacy in general  (GV01010J) ,  Basic research of psychotropic drugs  (GW03100Y) ,  Basic medicine on cardiovascular system  (GJ01020K)

Reference (39)：

• 1. Tsai P S, Kaufhold J P, Blinder P, Friedman B, Drew P J, Karten H J, Lyden P D, Kleinfeld D. Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci. 2009; 29:14553-14570.
• 2. Wu J, Guo C, Chen S, Jiang T, He Y, Ding W, Yang Z, Luo Q, Gong H. Direct 3D Analyses Reveal Barrel-Specific Vascular Distribution and Cross-Barrel Branching in the Mouse Barrel Cortex. Cerebral cortex. 2016; 26:23-31.
• 3. Wu J, He Y, Yang Z, Guo C, Luo Q, Zhou W, Chen S, Li A, Xiong B, Jiang T, Gong H. 3D BrainCV: Simultaneous visualization and analysis of cells and capillaries in a whole mouse brain with one-micron voxel resolution. NeuroImage. 2014; 87:199-208.
• 4. Kerr A L, Steuer E L, Pochtarev V, Swain R A. Angiogenesis but not neurogenesis is critical for normal learning and memory acquisition. Neuroscience. 2010; 171:214-226.
• 5. Kiuchi T, Lee H, Mikami T. Regular exercise cures depression-like behavior via VEGF-Flk-1 signaling in chronically stressed mice. Neuroscience. 2012; 207:208-217.

Terms in the title (7)： 難治性うつ病 ,  血管新生 ,  血液脳関門 ,  回避 ,  可能性 ,  表現型 ,  標的