Art

J-GLOBAL ID：201602232513592929   Reference number：16A1327697

Paneth cell α-defensins and enteric microbiota in health and disease

健康と疾患におけるPaneth細胞α-デフェンシン及び腸内細菌叢

Author (5)： NAKAMURA Kiminori (Department of Cell Biological Science, Graduate School of Life Science, Faculty of Advanced Life Science, Hokkaido University, Hokkaido 001-0021, Japan) ,  SAKURAGI Naoya (Department of Cell Biological Science, Graduate School of Life Science, Faculty of Advanced Life Science, Hokkaido University, Hokkaido 001-0021, Japan) ,  TAKAKUWA Akiko (Department of Cell Biological Science, Graduate School of Life Science, Faculty of Advanced Life Science, Hokkaido University, Hokkaido 001-0021, Japan) ,  TAKAKUWA Akiko (Department of Nutrition, Faculty of Nursing and Nutrition, Tenshi College, Hokkaido 065-0013, Japan) ,  AYABE Tokiyoshi (Department of Cell Biological Science, Graduate School of Life Science, Faculty of Advanced Life Science, Hokkaido University, Hokkaido 001-0021, Japan)
Material： Bioscience of Microbiota, Food and Health (Web)  (Biosci Microbiota Food Health (Web))
Volume： 35  Issue： 2  Page： 57-67(J-STAGE)  Publication year： 2016 
JST Material Number： U0398A  ISSN： 2186-3342  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： epithelial cell ,...
Semi thesaurus term： Paneth Cells ,...

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Author keywords (7)： Paneth cell ,  α-defensin ,  intestinal microbiota ,  innate immunity ,  dysbiosis ,  inflammatory bowel disease ,  lifestyle disease

JST classification (2)： Bioactive peptides  (EB08100U) ,  Biophylaxis and immune systems in general  (ED01010F)

Reference (115)：

• 1. Steiner H, Hultmark D, Engström A, Bennich H, Boman HG. 1981. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292: 246-248.
• 2. Selsted ME, Harwig SS, Ganz T, Schilling JW, Lehrer RI. 1985. Primary structures of three human neutrophil defensins. J Clin Invest 76: 1436-1439.
• 3. Zasloff M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415: 389-395.
• 4. Ganz T. 2003. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 3: 710-720.
• 5. Tomasinsig L, Zanetti M. 2005. The cathelicidins-structure, function and evolution. Curr Protein Pept Sci 6: 23-34.

Terms in the title (4)： 疾患 ,  Paneth細胞 ,  α-デフェンシン ,  腸内細菌叢