Art

J-GLOBAL ID：201602238839499016   Reference number：16A0751140

Therapeutic effect of intra-articular injection of ribbon-type decoy oligonucleotides for hypoxia inducible factor-1 on joint contracture in an immobilized knee animal model

固定膝動物モデルにおける低酸素誘導因子-1に対するリボン型デコイオリゴヌクレオチドの関節内注射の関節拘縮に対する治療効果

Author (6)： Sotobayashi Daisuke (Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan) ,  Kawahata Hirohisa (Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan) ,  Anada Natsuki (Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan) ,  Ogihara Toshio (Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan) ,  Morishita Ryuichi (Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Aoki Motokuni (Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan)
Material： Journal of Gene Medicine  (J Gene Med)
Volume： 18  Issue： 8  Page： 180-192  Publication year： Aug. 2016 
JST Material Number： W1804A  ISSN： 1099-498X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： laboratory animal ,...
Semi thesaurus term： Models, Animal ,...

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Author keywords (5)： drug delivery system ,  gene therapy ,  hypoxia hypoxia inducible factor ,  joint contracture ,  transcription factor

JST classification (3)： Gene manipulation  (EC02050B) ,  Basic medicine on musculoskeletal system  (GG01020B) ,  Nucleic acids in general  (EB04010U)

Reference (54)：

• Dudek N, Trudel G. Joint contractures. In Essentials of Physical Medicine and Rehabilitation, Musculoskeletal Disorders, Pain, and Rehabilitation (2nd edition). Frontera WR, Silver JK, Rizzo TD (eds). Saunders: Philadelphia, PA, 2008; 651-655.
• Akeson WH, Amiel D, Abel MF, Garfin SR, Woo SL. Effects of immobilization on joints. Clin Orthop Relat Res 1987; 219: 28-37.
• Trudel G, Laneuville O, Coletta E, Goudreau L, Uhthoff HK. Quantitative and temporal differential recovery of articular and muscular limitations of knee joint contractures; results in a rat model. J Appl Physiol 2014; 117: 730-737.
• Koh KH, Lim TK, Shon MS, et al. Effect of immobilization without passive exercise after rotator cuff repair: randomized clinical trial comparing four and eight weeks of immobilization. J Bone Joint Surg Am 2014; 96: e44.
• Hildebrand KA, Sutherland C, Zhang M. Rabbit knee model of post-traumatic joint contractures: the long-term natural history of motion loss and myofibroblasts. J Orthop Res 2004; 22: 313-320.

Terms in the title (9)： 膝 ,  動物 ,  モデル ,  低酸素誘導因子 ,  リボン ,  デコイオリゴヌクレオチド ,  関節内注射 ,  関節拘縮 ,  治療効果