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J-GLOBAL ID：201602240002727465   Reference number：16A0971772

Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes

機能性ポリマーを活用した三次元培養はHepaRG細胞の成熟肝細胞への分化を加速する

Author (7)： Higuchi Yichiro (Central Institute for Experimental Animals, Kawasaki, Japan) ,  Kawai Kenji (Central Institute for Experimental Animals, Kawasaki, Japan) ,  Kanaki Tatsuro (Nissan Chemical Industries, Shiraoka, Japan) ,  Yamazaki Hiroshi (Showa Pharmaceutical University, Tokyo, Japan) ,  Chesne Christophe (Biopredic International, Rennes, France) ,  Guguen-Guillouzo Christiane (Biopredic International, Rennes, France) ,  Suemizu Hiroshi (Central Institute for Experimental Animals, Kawasaki, Japan)
Material： Hepatology Research  (Hepatol Res)
Volume： 46  Issue： 10  Page： 1045-1057  Publication year： Sep. 2016 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *functional polymer ,...
Semi thesaurus term： CYP3A4

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Author keywords (4)： FP001 ,  HepaRG cells ,  TK-NOG mouse ,  3D culture

JST classification (2)： Basic medicine on digestive system  (GH01020E) ,  Cell and tissue culture methods  (EA03040R)

Substance index (2)： Omeprazole ,  Rifampin

Reference (31)：

• Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 2007 May 20; 168: 66-73.
• Kanebratt KP, Andersson TB. Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies. Drug Metab Dispos 2008 Jul; 36: 1444-52.
• Gripon P, Rumin S, Urban S et al. Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci U S A 2002 Nov 26; 99: 15 655-60.
• Cerec V, Glaise D, Gamier D et al. Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor. Hepatology 2007 Apr; 45: 957-67.
• Higuchi Y, Kawai K, Yamazaki H et al. The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice. Xenobiotica 2014 Jan; 44: 146-53.

Terms in the title (8)： 機能性ポリマー ,  活用 ,  三次元培養 ,  HepaRG細胞 ,  成熟 ,  肝細胞 ,  分化 ,  加速