Art

J-GLOBAL ID：201602241438325403   Reference number：16A1395579

Application of Microneedles to Skin Induces Activation of Epidermal Langerhans Cells and Dermal Dendritic Cells in Mice

皮膚への極微針の適用はマウスにおける表皮Langerhans細胞と真皮樹状細胞の活性化を誘発する

Author (6)： Takeuchi Asuka (Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.) ,  Nomoto Yusuke (Faculty of Pharmaceutical Sciences, Josai University) ,  Watanabe Mai (Faculty of Pharmaceutical Sciences, Josai University) ,  Kimura Soichiro (Faculty of Pharmaceutical Sciences, Josai University) ,  Morimoto Yasunori (Faculty of Pharmaceutical Sciences, Josai University) ,  Ueda Hideo (Faculty of Pharmaceutical Sciences, Josai University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 39  Issue： 8  Page： 1309-1318(J-STAGE)  Publication year： 2016 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,...
Semi thesaurus term： *microneedle ,...

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Author keywords (12)： microneedle ,  adjuvant-like effect ,  Langerhans cell ,  dermal dendritic cell ,  major histocompatibility complex (MHC) class-II ,  costimulatory molecule ,  microneedle ,  adjuvant-like effect ,  Langerhans cell ,  dermal dendritic cell ,  major histocompatibility complex (MHC) class-II ,  costimulatory molecule

JST classification (1)： Physicochemical pharmacy in general  (GV01010J)

Reference (54)：

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• 2) Ada G. Overview of vaccines. Methods Mol. Med., 87, 1-17 (2003).
• 3) Miller MA, Pisani E. The cost of unsafe injections. Bull. World Health Organ., 77, 808-811 (1999).
• 4) Nestle FO, Di Meglio P, Qin JZ, Nickoloff BJ. Skin immune sentinels in health and disease. Nat. Rev. Immunol., 9, 679-691 (2009).
• 5) Heath WR, Carbone FR. Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat. Immunol., 10, 1237-1244 (2009).

Terms in the title (9)： 皮膚 ,  針 ,  マウス ,  表皮 ,  Langerhans細胞 ,  真皮 ,  樹状細胞 ,  活性化 ,  誘発