Art

J-GLOBAL ID：201602245559233913   Reference number：16A0711754

Evaluation of the safety and efficacy of TY-51924 in patients with ST elevated acute myocardial infarction - Early phase II first in patient pilot study

ST上昇急性心筋梗塞患者におけるTY-51924の安全性と効果の評価 初期第II相の患者での最初のパイロット試験

Author (16)： Takayama Tadateru (Department of Cardiology, Nihon University Itabashi Hospital, Tokyo, Japan) ,  Kimura Kazuo (Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan) ,  Fukuzawa Shigeru (Division of Cardiology, Funabashi Municipal Medical Center Heart and Vascular Institute, Funabashi, Japan) ,  Hirayama Haruo (Department of Cardiology, Nagoya Daini Red Cross Hospital, Nagoya, Japan) ,  Sone Takahito (Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan) ,  Ueda Yasunori (Cardiovascular Division, Osaka National Hospital, Osaka, Japan) ,  Uematsu Masaaki (Kansai Rosai Hospital Cardiovascular Center, Hyogo, Japan) ,  Ishihara Masaharu (Division of Coronary Artery Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan) ,  Nakao Koichi (Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan) ,  Matsumoto Naoya (Department of Cardiology, Nihon University Hospital, Tokyo, Japan) ,  Kosuge Masami (Department of Cardiology, Yokohama Ekisaikai Hospital, Yokohama, Japan) ,  Hiro Takafumi (Division of Advanced Cardiovascular Image Analysis, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan) ,  Asakura Masanori (Department of Clinical Research, National Cerebral and Cardiovascular Center, Suita, Japan) ,  Kaneko Akira (Research & Development Department, TOA EIYO Ltd., Saitama, Japan) ,  Yokoi Toshiaki (Research & Development Department, TOA EIYO Ltd., Saitama, Japan) ,  Hirayama Atsushi (Department of Medicine, Division of Cardiology, Nihon University School of Medicine, Tokyo, Japan)
Material： Journal of Cardiology  (J Cardiol)
Volume： 67  Issue： 2  Page： 162-169  Publication year： Feb. 2016 
JST Material Number： W2218A  ISSN： 0914-5087  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *acute myocardial infarction ,...
Semi thesaurus term： *ST-elevation acute myocardial infarction ,...

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Author keywords (5)： Acute myocardial infarction ,  Percutaneous coronary intervention ,  Reperfusion injury ,  Cardioprotection ,  NHE inhibitor

JST classification (3)： Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M) ,  Clinical application of cardioactive drugs  (GW07030Y) ,  Postoperative treatment and prognosis  (GC07050M)

Reference (26)：

• Velagaleti RS, Pencina MJ, Murabito JM, Wang TJ, Parikh NI, D'Agostino RB, Levy D, Kannel WB, Vasan RS. Long-term trends in the incidence of heart failure after myocardial infarction. Circulation 2008;118:2057-62.
• Kloner RA. Does reperfusion injury exist in humans? J Am Coll Cardiol 1993;21:537-45.
• Braunwald E, Kloner RA. Myocardial reperfusion: a double-edged sword? J Clin Invest 1985;76:1713-9.
• Kaul S. The “no reflow“ phenomenon following acute myocardial infarction: mechanisms and treatment options. J Cardiol 2014;64:77-85.
• Trifunovic D, Stankovic S, Marinkovic J, Beleslin B, Banovic M, Djukanovic N, Orlic D, Tesic M, Vujisic-Tesic B, Petrovic M, Nedeljkovic I, Stepanovic J, Djordjevic-Dikic A, Giga V, Ostojic M. Time-dependent changes of plasma adiponectin concentration in relation to coronary microcirculatory function in patients with acute myocardial infarction treated by primary percutaneous coronary intervention. J Cardiol 2015;65:208-15.

Terms in the title (7)： ST上昇急性心筋梗塞 ,  患者 ,  安全性 ,  評価 ,  初期 ,  第II相 ,  パイロット試験