Art

J-GLOBAL ID：201602251134384539   Reference number：16A1032307

The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy

日本人の小児てんかん患者におけるラモトリギン消失に対する薬剤併用の効果

Author (20)： Takeuchi Tomoya (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Natsume Jun (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Kidokoro Hiroyuki (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Ishihara Naoko (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Yamamoto Hiroyuki (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Azuma Yoshiteru (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Ito Yuji (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Kurahashi Naoko (Department of Pediatric Neurology, Central Hospital, Aichi Human Service Center, Kasugai, Japan) ,  Tsuji Takeshi (Department of Pediatrics, Okazaki City Hospital, Okazaki, Japan) ,  Suzuki Motomasa (Aichi Children’s Health and Medical Center, Ohbu, Japan) ,  Itomi Kazuya (Aichi Children’s Health and Medical Center, Ohbu, Japan) ,  Yamada Keitaro (Department of Pediatric Neurology, Central Hospital, Aichi Human Service Center, Kasugai, Japan) ,  Kurahashi Hirokazu (Department of Pediatric Neurology, Central Hospital, Aichi Human Service Center, Kasugai, Japan) ,  Abe Shinpei (Department of Pediatrics, Juntendo University Hospital, Tokyo, Japan) ,  Okumura Akihisa (Department of Pediatrics, Juntendo University Hospital, Tokyo, Japan) ,  Maruyama Koichi (Department of Pediatric Neurology, Central Hospital, Aichi Human Service Center, Kasugai, Japan) ,  Negoro Tamiko (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Watanabe Kazuyoshi (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan) ,  Watanabe Kazuyoshi (Faculty of Health and Medical Sciences, Aichi Shukutoku University, Nagakute, Japan) ,  Kojima Seiji (Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan)
Material： Brain & Development  (Brain & Dev)
Volume： 38  Issue： 8  Page： 723-730  Publication year： Sep. 2016 
JST Material Number： W0814A  ISSN： 0387-7604  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...

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Author keywords (6)： Lamotrigine ,  Co-medication ,  Child ,  Epilepsy ,  Drug interaction ,  Drug concentration

JST classification (1)： Drug therapy(=pharmacotherapy)for nervous system diseases  (GN05020Y)

Substance index (1)： Lamotrigine

Reference (18)：

• Duchowny M, Pellock JM, Graf WD, Billard C, Gilman J, Casale E, et al. A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children. Neurology 1999;53:1724-31.
• Frank LM, Enlow T, Holmes GL, Manasco P, Concannon S, Chen C, et al. Lamictal (lamotrigine) monotherapy for typical absence seizures in children. Epilepsia 1999;40:973-9.
• Motte J, Trevathan E, Arvidsson JF, Barrera MN, Mullens EL, Manasco P. Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome. N Engl J Med 1997;337:1807-12.
• Veggiotti P, Cieuta C, Rex E, Dulac O. Lamotrigine in infantile spasms. Lancet 1994;344:1375-6.
• Armijo JA, Bravo J, Cuadrado A, Herranz JL. Lamotrigine serum concentration-to-dose ratio: influence of age and concomitant antiepileptic drugs and dosage implications. Ther Drug Monit 1999;21:182-90.

Terms in the title (6)： 日本人 ,  小児てんかん ,  患者 ,  ラモトリギン ,  薬剤 ,  併用