Art

J-GLOBAL ID：201602251826070988   Reference number：16A1305190

High-throughput discovery of novel developmental phenotypes

新しい発生表現型のハイスループットな発見

Author (120)： DICKINSON Mary E. (Dep. of Molecular Physiology and Biophysics, Texas, USA) ,  HSU Chih-Wei (Dep. of Molecular Physiology and Biophysics, Texas, USA) ,  KALAGA Sowmya (Dep. of Molecular Physiology and Biophysics, Texas, USA) ,  KEITH Lance C. (Dep. of Molecular Physiology and Biophysics, Texas, USA) ,  MCELWEE Melissa L. (Dep. of Molecular Physiology and Biophysics, Texas, USA) ,  WONG Leeyean (Dep. of Molecular Physiology and Biophysics, Texas, USA) ,  FLENNIKEN Ann M. (Toronto Centre for Phenogenomics, Ontario, CAN) ,  WONG Michael D. (Toronto Centre for Phenogenomics, Ontario, CAN) ,  ADISSU Hibret (Toronto Centre for Phenogenomics, Ontario, CAN) ,  NEWBIGGING Susan (Toronto Centre for Phenogenomics, Ontario, CAN) ,  NUTTER Lauryl M. J. (Toronto Centre for Phenogenomics, Ontario, CAN) ,  GUO Ruolin (Toronto Centre for Phenogenomics, Ontario, CAN) ,  QU Dawei (Toronto Centre for Phenogenomics, Ontario, CAN) ,  SPRING Shoshana (Toronto Centre for Phenogenomics, Ontario, CAN) ,  YU Lisa (Toronto Centre for Phenogenomics, Ontario, CAN) ,  ELLEGOOD Jacob (Toronto Centre for Phenogenomics, Ontario, CAN) ,  MORIKAWA Lily (Toronto Centre for Phenogenomics, Ontario, CAN) ,  SHANG Xueyuan (Toronto Centre for Phenogenomics, Ontario, CAN) ,  FEUGAS Pat (Toronto Centre for Phenogenomics, Ontario, CAN) ,  CREIGHTON Amie (Toronto Centre for Phenogenomics, Ontario, CAN) ,  PENTON Patricia Castellanos (Toronto Centre for Phenogenomics, Ontario, CAN) ,  DANISMENT Ozge (Toronto Centre for Phenogenomics, Ontario, CAN) ,  HENKELMAN R. Mark (Toronto Centre for Phenogenomics, Ontario, CAN) ,  MCKERLIE Colin (Toronto Centre for Phenogenomics, Ontario, CAN) ,  FLENNIKEN Ann M. (Mount Sinai Hospital, Ontario, CAN) ,  JI Xiao (Univ. Pennsylvania, Pennsylvania, USA) ,  TEBOUL Lydia (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  WESTERBERG Henrik (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  BROWN James M. (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  CLEAK James (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  HORNER Neil R. (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  JOHNSON Sara J. (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  LAWSON Thomas N. (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  SZOKE-KOVACS Zsombor (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  STEWART Michelle E. (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  COPLEY Carol (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  HARRISON Jackie (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  JOYNSON Samantha (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  WELLS Sara (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  MALLON Ann-Marie (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  BROWN Steve D. M. (Medical Res. Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Oxfordshire, GBR) ,  WONG Michael D. (Hospital for Sick Children, Ontario, CAN) ,  HENKELMAN R. Mark (Hospital for Sick Children, Ontario, CAN) ,  WHITE Jacqueline K. (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  DOE Brendan (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  GALLI Antonella (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  RAMIREZ-SOLIS Ramiro (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  RYDER Edward (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  GRIGGS Nicola (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  TUDOR Catherine L. (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  GREEN Angela L. (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  MAZZEO Cecilia Icoresi (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  SIRAGHER Emma (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  LILLISTONE Charlotte (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  TUCK Elizabeth (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  GLEESON Diane (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  SETHI Debarati (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  BAYZETINOVA Tanya (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  BURVILL Jonathan (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  HABIB Bishoy (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  WEAVERS Lauren (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  MASWOOD Ryea (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  MIKLEJEWSKA Evelina (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  WOODS Michael (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  GRAU Evelyn (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  NEWMAN Stuart (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  SINCLAIR Caroline (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  BROWN Ellen (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  BRADLEY Allan (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  SKARNES William C. (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  ADAMS David J. (Wellcome Trust Sanger Inst., Cambridge, GBR) ,  MEEHAN Terrence F. (European Bioinformatics Inst., Cambridge, GBR) ,  MASON Jeremy (European Bioinformatics Inst., Cambridge, GBR) ,  TUDOSE Ilinca (European Bioinformatics Inst., Cambridge, GBR) ,  WARREN Jonathan (European Bioinformatics Inst., Cambridge, GBR) ,  FLICEK Paul (European Bioinformatics Inst., Cambridge, GBR) ,  PARKINSON Helen E. (European Bioinformatics Inst., Cambridge, GBR) ,  WENINGER Wolfgang J. (Medical Univ. Vienna, Vienna, AUT) ,  ADISSU Hibret (Hospital for Sick Children, Ontario, CAN) ,  NEWBIGGING Susan (Hospital for Sick Children, Ontario, CAN) ,  NUTTER Lauryl M. J. (Hospital for Sick Children, Ontario, CAN) ,  JUSTICE Monica J. (Hospital for Sick Children, Ontario, CAN) ,  MCKERLIE Colin (Hospital for Sick Children, Ontario, CAN) ,  BAKER Candice N. (Jackson Lab., Maine, USA) ,  CADDLE L. Brianna (Jackson Lab., Maine, USA) ,  DENEGRE James M. (Jackson Lab., Maine, USA) ,  DOLAN Mary E. (Jackson Lab., Maine, USA) ,  EDIE Sarah M. (Jackson Lab., Maine, USA) ,  PETERSON Kevin A. (Jackson Lab., Maine, USA) ,  MCKAY Matthew (Jackson Lab., Maine, USA) ,  URBAN Barbara (Jackson Lab., Maine, USA) ,  LUND Caroline (Jackson Lab., Maine, USA) ,  FROETER Erin (Jackson Lab., Maine, USA) ,  LACASSE Taylor (Jackson Lab., Maine, USA) ,  MEHALOW Adrienne (Jackson Lab., Maine, USA) ,  GORDON Emily (Jackson Lab., Maine, USA) ,  DONAHUE Leah Rae (Jackson Lab., Maine, USA) ,  TAFT Robert (Jackson Lab., Maine, USA) ,  KUTNEY Peter (Jackson Lab., Maine, USA) ,  DION Stephanie (Jackson Lab., Maine, USA) ,  GOODWIN Leslie (Jackson Lab., Maine, USA) ,  KALES Susan (Jackson Lab., Maine, USA) ,  URBAN Rachel (Jackson Lab., Maine, USA) ,  PALMER Kristina (Jackson Lab., Maine, USA) ,  BRAUN Robert E. (Jackson Lab., Maine, USA) ,  SVENSON Karen L. (Jackson Lab., Maine, USA) ,  MURRAY Stephen A. (Jackson Lab., Maine, USA) ,  BOWER Lynette (Univ. California, Davis, California, USA) ,  CLARY Dave (Univ. California, Davis, California, USA) ,  LANOUE Louise (Univ. California, Davis, California, USA) ,  ROWLAND Douglas J. (Univ. California, Davis, California, USA) ,  TRAINOR Amanda G. (Univ. California, Davis, California, USA) ,  LLOYD K. C. Kent (Univ. California, Davis, California, USA) ,  CHIANI Francesco (Monterotondo Mouse Clinic, Italian National Res. Council (CNR), Monterotondo Scalo, ITA) ,  GAMBADORO Alessia (Monterotondo Mouse Clinic, Italian National Res. Council (CNR), Monterotondo Scalo, ITA) ,  TOCCHINI-VALENTINI Glauco P. (Monterotondo Mouse Clinic, Italian National Res. Council (CNR), Monterotondo Scalo, ITA) ,  DALY Mark J. (Massachusetts General Hospital, Massachusetts, USA) ,  LEK Monkol (Massachusetts General Hospital, Massachusetts, USA) ,  SAMOCHA Kaitlin E. (Massachusetts General Hospital, Massachusetts, USA) ,  MACARTHUR Daniel G. (Massachusetts General Hospital, Massachusetts, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 537  Issue： 7621  Page： 508-514  Publication year： Sep. 22, 2016 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *phenotype ,  throughput ,  *knockout mouse ,  manufacturing ,  *lethal gene ,  *ontogenesis ,  nucleotide sequence
Semi thesaurus term： high throughput ,  *imaging

JST classification (2)： Gene expression  (EC02040Q) ,  Cell physiology in general  (EF02010S)

Terms in the title (3)： 表現型 ,  ハイスループット ,  発見