Art

J-GLOBAL ID：201602255056694349   Reference number：16A1196837

Mass Spectrometric Approaches to the Identification of Potential Ingredients in Cigarette Smoke Causing Cytotoxicity

細胞毒性を引き起こすタバコ煙中の潜在的成分の同定への質量分析アプローチ

Author (4)： Horiyama Shizuyo (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Kunitomo Masaru (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Yoshikawa Noriko (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University) ,  Nakamura Kazuki (School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University)
Material： Biological and Pharmaceutical Bulletin  (Biological & Pharmaceutical Bulletin)
Volume： 39  Issue： 6  Page： 903-908(J-STAGE)  Publication year： 2016 
JST Material Number： S0989A  ISSN： 0918-6158  CODEN： BPBLEO  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cytotoxicity ,...
Semi thesaurus term： *tobacco smoke

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Author keywords (6)： glutathione (GSH) ,  αβ-unsaturated carbonyl compound ,  LC/MS ,  glutathione (GSH) ,  αβ-unsaturated carbonyl compound ,  LC/MS

JST classification (1)： Analysis of drugs  (GV01040Q)

Substance index (3)： Acrolein ,  Crotonaldehyde ,  Methyl vinyl ketone

Reference (23)：

• 1) Shah PK, Helfant RH. Smoking and coronary artery disease. Chest, 94, 449-452 (1988).
• 2) Hoffmann D, Hoffmann I, El-Bayoumy K. The lsee harmful cigarette: a controversial issue. A tribute to Ernst L. Wynder. Chem. Res. Toxicol., 14, 767-790 (2001).
• 3) Einaga H, Yoshihara E, Matsuo Y. Oxidative stress and redox regulation-protein oxidative modification. J. Anal. Biomed. Sci., 32, 265-272 (2009).
• 4) Kunitomo M, Yamaguchi Y, Kagota S, Yoshikawa N, Nakamura K, Shinozuka K. Biochemical evidence of atherosclerosis progression mediated by increased oxidative stress in apolipoprotein E-deficient spontaneously hyperlipidemic mice exposed to chronic cigarette smoke. J. Pharmacol. Sci., 110, 354-361 (2009).
• 5) Yamaguchi Y, Kagota S, Haginaka J, Kunitomo M. Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke. FEBS Lett., 512, 218-222 (2002).

Terms in the title (4)： 細胞毒性 ,  タバコ煙 ,  同定 ,  質量分析