Art

J-GLOBAL ID：201602259095237079   Reference number：16A1395974

Cross-Neutralization Activity of Single-Chain Variable Fragment (scFv) Derived from Anti-V3 Monoclonal Antibodies Mediated by Post-Attachment Binding

接着後結合に仲介される,抗V3モノクローナル抗体由来の単鎖可変フラグメント(scFv)の交差中和活性

Author (9)： Maruta Yasuhiro (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University) ,  Kuwata Takeo (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University) ,  Tanaka Kazuki (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University) ,  Alam Muntasir (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University) ,  Valdez Kristel Paola Ramirez (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University) ,  Egami Yoshika (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University) ,  Suwa Yoshiaki (Department of Analytical and Biophysical Chemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University) ,  Morioka Hiroshi (Department of Analytical and Biophysical Chemistry, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University) ,  Matsushita Shuzo (Matsushita Project Laboratory, Center for AIDS Research, Kumamoto University)
Material： Japanese Journal of Infectious Diseases  (日本感染症雑誌)
Volume： 69  Issue： 5  Page： 395-404(J-STAGE)  Publication year： 2016 
JST Material Number： F0552A  ISSN： 1344-6304  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： HIV1 ,...
Semi thesaurus term： *scFv ,...

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Author keywords (3)： HIV-1 ,  monoclonal antibody ,  single-chain variable fragment (scFv)

JST classification (1)： Physiology and pathogenicity of virus infection  (EG04042Y)

Reference (40)：

• 1. Hope TJ. Moving ahead an HIV vaccine: to neutralize or not, a key HIV vaccine question. Nat Med. 2011;17:1195-7.
• 2. Mascola JR, Haynes BF. HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol Rev. 2013;254:225-44.
• 3. Burton DR, Mascola JR. Antibody responses to envelope glycoproteins in HIV-1 infection. Nat Immunol. 2015;16:571-6.
• 4. Center RJ, Leapman RD, Lebowitz J, et al. Oligomeric structure of the human immunodeficiency virus type 1 envelope protein on the virion surface. J Virol. 2002;76:7863-7.
• 5. Pantophlet R, Burton DR. GP120: target for neutralizing HIV-1 antibodies. Annu Rev Immunol. 2006;24:739-69.

Terms in the title (8)： 仲介 ,  モノクローナル抗体 ,  可変 ,  フラグメント ,  scFv ,  交差 ,  中和 ,  活性